Drug Metabolism

Question 1

Char-broiled food, Cruciferous Vegetables, and Cigarette Smoking all affect CYP_____

Answer 1

1A

Question 2

Phase II reactions are also known as _____ reactions, which make highly polar end products. (Glutathione or Glucuronic Acid)

Answer 2

Conjugation

Question 3

Alcohol consumption affects CYP____

Answer 3

2E

Question 4

Which herb is a major Inductor of CYP3A metabolism?

Answer 4

St. John’s Wort

Question 5

To overcome the toxic Acetaminophen by-product; _____ performs conjugation to result in Acetyl-Mercapturate

Answer 5

Glutathione

Question 6

Enzymes that catalyze Phase I reactions are also known as ______ reactions

Answer 6

Functionalization

Question 7

Glucuronidation, N-Acetylation, Glutathione Conugation, Sulfation, and Methylation all happen with conjugation reactions with Phase ____ reactions

Answer 7

II

Question 8

Two main CYP enzymes

Answer 8

1. CYP3A
2. CYP2D6

Question 9

Which fruit is a major inhibitor of CYP3A4

Answer 9

Grapefruit

Question 10

When Acetaminophen gets a _____ group attached by CYP450, you get a reactive electrophilic compound that binds to a protein and causes Hepatic cell death.

Answer 10

Hydroxyl

Question 11

Two synthetic forms of _____ known as _____ and _____ are used to treat Toxic Acetaminophen-Reactive Compount

Answer 11

• Glutathione
• Cysteamine
• N-acetylcysteine