Pharmacokinetic And Pharmacodynamic (Exam 1) Flashcards
What is pharmacokinetic
This is how the drug moves or travels through the body
What are the 4 processes of pharmacokinetic
Absorption
Distribution
Metabolism
Excretion
How can you define absorption
The movement of the drug into the bloodstream
Name the 4 factors that affect absorption
The form of the drug
Route of administration
Age of patient
Ph of GI tract
How do enteric drugs work
It does not disintegrate until the medication is present in the alkaline environment
Why should you not crush enteric drugs
It affects the time and place of the absorption
It might be absorbed where it shouldn’t be absorbed
Which routes of administration is absorbed fast?
IV
Sublingual
Inhale
Routes or administration that are slow
IM
SUB Q
Which IM administration site has fast absorption and which one has slow absorption
Fats is deltoid
Slow is the bottom
Which age group has slow absorption of medication and why
The older adults because they have less gastric acidity
What is bioavailability
The percentage of the drug that is remaining for distribution or activity
What are the factors that affects the bioavailability of the drug
Route
Form of drug
Gastric mucosa and mobility
Administration with foods and other drugs
Which on has more bioavailability IV or ORAL
IV
Explain the first past effect
After the drug is absorbed it goes to the small intestine and then goes to the liver.
In the liver some of the drug is metabolized to an inactive form and is excreted
What is the result of the first pas effect
The drug % lowers
