pharmacogenomics

Question 1

ABCG2 is an exporter or importor of the statin ?

Answer 1

exporter

Question 2

wildtype for ABCG2

Answer 2

CC

Question 3

SNP for ABCG2

Answer 3

AA

Question 4

SNP for ABCG2 leading to increase plasma concentration of statin Y/N

Answer 4

Y

Question 5

for rosuvastin, normal and heterozygous of ABCG2 are not recommended for dose adjustment (CC / CA ) Y/N

Answer 5

Y

Question 6

homozygous of ABCG2 (AA)—less than 20 mg (if goes over, consider switch to another one) Y/N

Answer 6

Y

Question 7

ALCO1B1 is an exporter or importor of the statin ?

Answer 7

importer

Question 8

wild type of SLCO1B1

Answer 8

TT

Question 9

SNP for SLCO1B1

Answer 9

CC

Question 10

SNP for SLCO1B1 leading to increase plasma concentration of statin Y/N (why?)

Answer 10

Y (reduced uptake by the liver–increase plasma conc）

Question 11

for ppl with reduced SLCO1B1 function—avoid

Answer 11

simvastatin 20-40 mg
atorrvastin 80 mg

Question 12

for ppl with reduced SLCO1B1 fucntion—be autions with

Answer 12

simvastatin 10 mg
atorvastatin 40 mg
rosuvastatin 40 mg

Question 13

for ppl with poor SCOL1B1 fuction—avoid

Answer 13

simvastatin—10 mg & 20-40 mg
atorvastatin—40–80g
rosuvastin—40 mg

Question 14

which liver enzyme is associated with warfarin

Answer 14

CYP2C9 (elimination)

Question 15

which liver enzyme is associated with clopidogrel

Answer 15

CYP2C19 (activation)