digoxin

Question 1

Sx for digoxin toxicity

Answer 1

headache / confusion / depression / nausea

slow and irregular HB

blurred visual (disturbance)

stomach pain / diarrhoea / vomitting

Question 2

how to treat digoxin toxicity

Answer 2

digoxin specific antibody

Question 3

who is more suspectible to digoxin toxicity ?

Answer 3

age (prone in old ppl)

severity of the disease (the dose we would use)

cormobidities (electrolytes abnormality / thyroid gland abnormalities) / drug drug interactions

renal impairment (digoxin is renally cleaned)

Question 4

should we consider the time which the sample was taken ? Y/ N (why time matters)

Answer 4

Y / trought conc or not (6-10 days )

Question 5

will the patient’s adherence to the drug influecen the Y/N

Answer 5

Y

Question 6

typical drug-drug interactions with digoxin

Answer 6

amiodarone (increase the conc of digoxin_

Question 7

is digoxin a substrate of p-gp Y/N

Answer 7

Y

Question 8

conc of digoxin should not exceed

Answer 8

2 ng /

Question 9

how the conc of digoxin is measured

Answer 9

overall mechanism—digoxin compete with the substrate for the binding site—once bind—it reduces the enzyem activity—change in the absorbance

Question 10

digoxin has a positive or negative inotropic effect

Answer 10

positive

Question 11

target of digoxin

Answer 11

Na+ / K+ ATP pump