Asthma Flashcards
Asthma
list all SABA
salbutamol + terbutaline
what does SABA stands for
short-acting beta agonist
what type of beta receptor does the SABA and LABA target
beta-2
what kind of intercelluar recetions it triggers
increase the conversion of ATP to cAMP
upregulate the PKA level—pull the ca2+ back to the SR
overall-bronchodilation
all long beta receptor end with
terol
can low dose budesonide and formoterol act as reliver Y/N
Y
adverse effect of SABA
tremor
why overuse of SAMA
down regulate the num of the receptor
why for some ppl overuse SABA does not lead to severe consequence
polymorphism
can LABA be used by its own ? Y/N
N
describe the symbiotic effect of LABA and ICS
ICS could upregulate the effet
list SAMA
ipratropium
describe how M2 is different from M3
M3 only presents in the post synaptic area while M2 receptor presents in both pre and post synaptic areas and has opposite effect
describe how muscarinic receptor causes bronchoconstriction
PKC—stimulate the release of Ca2+ from the SR—increase the intracelluar Ca2+ level
theophyline is a
phosphodiesterase inhibitor
how phosphodiesterase inhibitor casues bronchodilation
increase cAMP level
is ipratropium a SAMA or LAMA
SAMA
SAMA is more beneficial than SABA in asthma management Y/N
N
is tiotropium a SAMA or LAMA
LAMA
tiotropium can be used as a add-on
what’s conclude in a triple therapy
aspirin-induced repiratory diseases are more prne to happen among patients wiht severe asthma _ naasl poly + chronoc rtY/N
Y
mechanism of action of MgSO4
inhibit Ca2+ influx
inhibit histamine release from the mast cell
Ach release from cholinergic receptor
increase the affinity of beta-2 receptor
good asthma control
day time sx < 2 days / wk
no sx when walking or at night
no limitation to the activities
need reliver < 2 / wk
asthma management for 1-5 yrs
SABA
ICS / Montelukast + SABA
ICS (higher dose) & ICS / montelukast + SABA
asthma management for 6-11 yrs
SABA
ICS / Montelukast + SABA
ICS (higher dose) & ICS / montelukast & ICS / LABA +SABA
asthma > 12
SABA
ICS / SABA & budesonide+ fermoterol (as needed_
ICS / LABA (low dose-daily and as needed) & ICS/ LABA (daily) SABA as needed
increase the dose
phenotypes of asthma
Th2 high and Th2 low
IL produced by Th2 cells
IL-5—recruit eosinophils
IL4 / IL-13—mast cells
features of Th2 high asthma
increased eosinophis level
could be slightly prone to have more inflammation feature
terbutaline is PBS listed only when the salbutamol is not appropriate for the patient Y/N
Y
