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phar 3816 > Asthma > Flashcards

Asthma Flashcards

Asthma

1
Q

list all SABA

A

salbutamol + terbutaline

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2
Q

what does SABA stands for

A

short-acting beta agonist

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3
Q

what type of beta receptor does the SABA and LABA target

A

beta-2

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4
Q

what kind of intercelluar recetions it triggers

A

increase the conversion of ATP to cAMP
upregulate the PKA level—pull the ca2+ back to the SR
overall-bronchodilation

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5
Q

all long beta receptor end with

A

terol

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6
Q

can low dose budesonide and formoterol act as reliver Y/N

A

Y

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7
Q

adverse effect of SABA

A

tremor

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8
Q

why overuse of SAMA

A

down regulate the num of the receptor

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9
Q

why for some ppl overuse SABA does not lead to severe consequence

A

polymorphism

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10
Q

can LABA be used by its own ? Y/N

A

N

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11
Q

describe the symbiotic effect of LABA and ICS

A

ICS could upregulate the effet

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12
Q

list SAMA

A

ipratropium

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13
Q
A
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14
Q

describe how M2 is different from M3

A

M3 only presents in the post synaptic area while M2 receptor presents in both pre and post synaptic areas and has opposite effect

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15
Q

describe how muscarinic receptor causes bronchoconstriction

A

PKC—stimulate the release of Ca2+ from the SR—increase the intracelluar Ca2+ level

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16
Q

theophyline is a

A

phosphodiesterase inhibitor

17
Q

how phosphodiesterase inhibitor casues bronchodilation

A

increase cAMP level

18
Q

is ipratropium a SAMA or LAMA

A

SAMA

19
Q

SAMA is more beneficial than SABA in asthma management Y/N

A

N

20
Q

is tiotropium a SAMA or LAMA

A

LAMA

21
Q

tiotropium can be used as a add-on

A
22
Q

what’s conclude in a triple therapy

A
23
Q

aspirin-induced repiratory diseases are more prne to happen among patients wiht severe asthma _ naasl poly + chronoc rtY/N

A

Y

24
Q

mechanism of action of MgSO4

A

inhibit Ca2+ influx
inhibit histamine release from the mast cell
Ach release from cholinergic receptor
increase the affinity of beta-2 receptor

25
Q

good asthma control

A

day time sx < 2 days / wk
no sx when walking or at night
no limitation to the activities
need reliver < 2 / wk

26
Q

asthma management for 1-5 yrs

A

SABA
ICS / Montelukast + SABA
ICS (higher dose) & ICS / montelukast + SABA

27
Q

asthma management for 6-11 yrs

A

SABA
ICS / Montelukast + SABA
ICS (higher dose) & ICS / montelukast & ICS / LABA +SABA

28
Q

asthma > 12

A

SABA
ICS / SABA & budesonide+ fermoterol (as needed_
ICS / LABA (low dose-daily and as needed) & ICS/ LABA (daily) SABA as needed
increase the dose

29
Q

phenotypes of asthma

A

Th2 high and Th2 low

30
Q

IL produced by Th2 cells

A

IL-5—recruit eosinophils
IL4 / IL-13—mast cells

31
Q

features of Th2 high asthma

A

increased eosinophis level
could be slightly prone to have more inflammation feature

32
Q

terbutaline is PBS listed only when the salbutamol is not appropriate for the patient Y/N

A

Y

phar 3816 (13 decks)

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