hyperlipidemia

Question 1

mechanism of action for TZD

Answer 1

bind to PPAR (gamma)—increase insulin sensitivity
up-regulate the speed of FA metabolism
NOTE: it triggers a series changes and eventually regulates the gene expression

Question 2

mechanims of action for CETP inhibitor

Answer 2

inhibit the enzyme CETP which can transfer the cholsterol back to the VDLD and LDL
increase the level of the HDL

Question 3

Ezetimibe target at the NPC1L1 receptor Y/N

Answer 3

Y

Question 4

bile acid sequestrant is positively charged Y/N

Answer 4

Y

Question 5

mechanism of action for fibrate

Answer 5

upregulate the expression of LPL (lipoprotein lipase)
down regulate the expression of Apo C
increase the FA metabolism
PPAP(alpha)–promote reverse cholesterol transport —ABCA1
esp usful for decreasing TG level

Question 6

mechanism of action for MTP

Answer 6

inhibit the synthesis of ApoB—reduce the production of VLDL and chylomicrone

Question 7

FH (familial hypercholsterol) is caused by mutuations in what types of genes

Answer 7

LDL receptor
PCSK 9
Apo B

Question 8

LDL is linked to the level of

Answer 8

cholesterol

Question 9

chylomicrone and VDLD is linked to the level of

Answer 9

TG

Question 10

elevated of LDL level has the most dramatic effect on atherosclerosis Y/N

Answer 10

Y

Question 11

hypercholsterol is chateracterized by

Answer 11

increases LDL level

Question 12

casues for hypercholsterol

Answer 12

FH (lack of LDL receptor / Apo B / PCSK 9)
polygenetic

Question 13

hypertriglyceride is characterized by

Answer 13

increased VLDL level and chylomicron

Question 14

casues for hypertriglyceride

Answer 14

LPL deficiency
ApoIIC deficiency

Question 15

what is the fucntiion of ApoII C

Answer 15

co-factor of the LPL

Question 16

ApOB for chylomicrons

Answer 16

Apo B 48

Question 17

fucntion of cholsterol (3 fucntions)

Answer 17

cell membrane
steroid hormones / bil acid and bile salt
precursor of vit D