Pharmacogeneticss

Question 1

Methods in Molecular Genotyping

Answer 1

Polymerase Chain Reaction (PCR)

Restriction Fragment Length Polymorphism Mapping

Question 2

[T/F] In ultra-rapid metabolizers, there may be observed therapeutic failure when administering drugs.

Answer 2

T.
However, in the case of prodrugs, there is risk of ADR in ultra-rapid metabolizers because drug is rapidly converted to active component –> high levels –> leading to toxicity

Question 3

[T/F] Poor metabolizers cannot easily reach theraputic levels when given prodrugs.

Answer 3

T.

They cannot easily convert drug into active metabolites –> no effect

Question 4

Most severe form of pseudocholinesterase enzyme mutation

Answer 4

homozygous for the silent Es genotype – no detectable enzyme activity –> may exhibit muscle paralysis for as long as 8hrs

Question 5

[T/F] “Trial and Error” mechanism is currently practiced in determining the efficacy and safety of drugs.

Answer 5

T