Adrenergic Agents and Blockers

Question 0

Alpha-2 receptors: location, mechanism

Answer 0

Location: presynaptic adrenergic nerve terminals, smc
Mechanism: Gi protein inhibits AC, decreased cAMP, act like blockers

Question 1

Alpha-1 receptors: location and mechanism

Answer 1

Location: postsynaptic effector, smooth muscles (esp. bv), glands
Mechanism: Gq protein activates phospholipase C

Question 2

Beta-1 receptors: location, mechanism

Answer 2

Location: postsynaptic (HEART, lipocytes), presynaptic (JG cells)
Mechanism: Gs protein stimulates AC, increased cAMP

Question 3

Beta-2 receptors: location, mechanism

Answer 3

Location: postsynaptic (smc, LUNGS, cardiac)
Mechanism: Gs protein stimulates AC, increased cAMP

Question 4

Beta-3 receptors: location, mechanism

Answer 4

Location: postsynaptic especially LIPOCYTES
Mechanism: Gs protein stimulate AC, increased cAMP

Question 5

D1 and D5 receptors

Answer 5

Increase cAMP thru Gs protein

Question 6

D2, D3, D4

Answer 6

Decrease cAMP through Gi protein

Question 7

Remember the adrenergic agonist diagram?

Answer 7

RECALL!!!!!

Question 8

Remember the adrenergic antagonist diagram?

Answer 8

RECALL!!!!!!