Autacoids

Question 1

Triple response by Lewsi

Answer 1

flush, wheal, flare

Question 2

Representative antagonist of H receptors

Answer 2

H1: chlorphenamine
H2: ranitidine
H3: thioperamide, clobenpropit
H4: JNJ7777120, thioperamide

Question 3

[T/F] H3 receptors are found in parietal and cardiac cells.

Answer 3

F. H2 dapat :)

Question 4

[T/F] H4 receptors are found in hematopoietic cells.

Answer 4

T

Question 5

[T/F] H1 and H2 block is needed for the complete suppression of vascular smooth muscle contraction.

Answer 5

T

Question 6

[T/F] H4 blockers block the Type I hypersensitivity reaction.

Answer 6

F. H1 dapat :)

Question 7

Example of KKK inhibitor

Answer 7

Aprotinin

Question 8

Buspirone: receptor, action, clinical distribution

Answer 8

5-HT1A
partial agonist
anxiety, depression

Question 9

Sumatriptan: receptor, action, clinical distribution

Answer 9

5-HT1D
agonist
migraine

Question 10

Trazodone: receptor, action

Answer 10

5-HT2

agonist

Question 11

Risperidone, Ketanserin: receptor, action, clinical distribution

Answer 11

5-HT2A/2C
antagonist
migraine, depression, schizphrenia

Question 12

Ondansetron: receptor, action, clinical distribution

Answer 12

5-HT3
antagonist
chemical-induced emesis for cancer, nociception

Question 13

Cisapride, metoolopramide: receptor, action, clinical distribution

Answer 13

5-HT4

agonist, GI peristalsis

Question 14

Fluoxetine, Sertraline: receptor, action, clinical distribution

Answer 14

5-HT transporter
agonist (reuptake inhibitor)
major depression, OC

Question 15

Ergosmine, LSD: receptor, action, clinical distribution

Answer 15

non-selective

agonist

Question 16

Examples: ACE inhibitors

Answer 16

Captopril, Enalapril, Lisinopril

Question 17

Examples: Angiontensin II Receptor Blockers

Answer 17

Losartan, Valsartan, Irbesartan, Telmisartan, Candesartan (-sartans!)

Question 18

Examples: Renin inhibitors

Answer 18

Aliskirein