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THER 201 EXAM 2 REVIEW > Intro To CNS and Autonomic Pharmacology > Flashcards

Intro To CNS and Autonomic Pharmacology Flashcards

0
Q

Levo-DOPA: site of action

A

Synthesis of transmitter, enhances neurotransmitter production

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1
Q

Tetradotoxin: site of drug action

A

Action potential in presynaptic nerve fiber, blocks Na channels

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2
Q

Clostridium botulinum: site of action

A

Release of NT, prevents vesicular binding and release of Ach

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3
Q

Tricyclic depressants, SSRIs: site of action

A

Reuptake of NT

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4
Q

Pyrodostigmine: site of action

A

Degradation of NT, for myasthenia gravis (inhibits Achesterase)

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5
Q

Strychnine: moa

A

Selectively antagonizes both glycine and IPSPs in spinal cord ➡️ sever muscle spasms

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6
Q

Tetanus toxin: moa

A

Selectively prevent glycine release from inhibitory interneurons ➡️ muscle spasms

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7
Q

Vigabatrine: moa

A

Degradation, inhibits catalysis of GABA by GABA-transaminase

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8
Q

Benzodiazepine, barbiturate, zolpidem

A

Sedative-hypnotics, acts on GABAa receptor

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9
Q

Gabapentine, tiagabine, vigabatrine

A

Anticonvulsants, act on GABAa

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10
Q

Muscimol

A

Hallucinogenic mushroom, acts on GABAa

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11
Q

Picrotoxin, bicuculline

A

Acts on GABAa receptors

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12
Q

GABAa receptors: mechanism

A

Open Cl channels, block fast IPSP

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13
Q

Baclofen

A

Selectively activates GABAb receptors

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14
Q

GABAb receptors: mechanism

A

Inhibits Ca channels, or activate K channels ➡️ hyperpolarization

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15
Q

Memantine

A

NMDA antagonist, slows down cell death of memory neurons

16
Q

Ketamine

A

Selective blocker of NMDA receptors

17
Q

Mg2+ site of drug action

A

Blocks NMDA receptors

18
Q

Phencyclidine

A

No therapeutic diseases, cause strong hallucinations

19
Q

Vesamicol: site of drug action

A

Blocks vesicular Ach transporter

20
Q

Tacrine: site of drug action

A

Act on muscarinic receptors

21
Q

Phenothiazine, chlorpromazine, haloperidol

A

Dopamine antagonist, anti-psychotic but can cause Parkinsonian symptoms

22
Q

Bromocriptine, pergolide

A

Antiparkinsonism, dopamine agonist

23
Q

Clonidine, methyldopa

A

Decrease discharge of sympathetic nerves

24
Q

Amphetamines, cocaine

A

CNS stimulants, enhance noradrenergic pathways

25
Q

Phenelzine

A

Monoamine oxidase inhibitor, enhance noadrenergic pathways

26
Q

Reserpine

A

For hypertension, depletes vesicular stores of serotonin and norepinephrine in CNS neurons

27
Q

Morphine

A

Opiod analgesic, activation of receptors for endogenous peptides

THER 201 EXAM 2 REVIEW (9 decks)

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