Intro To CNS and Autonomic Pharmacology Flashcards
Levo-DOPA: site of action
Synthesis of transmitter, enhances neurotransmitter production
Tetradotoxin: site of drug action
Action potential in presynaptic nerve fiber, blocks Na channels
Clostridium botulinum: site of action
Release of NT, prevents vesicular binding and release of Ach
Tricyclic depressants, SSRIs: site of action
Reuptake of NT
Pyrodostigmine: site of action
Degradation of NT, for myasthenia gravis (inhibits Achesterase)
Strychnine: moa
Selectively antagonizes both glycine and IPSPs in spinal cord ➡️ sever muscle spasms
Tetanus toxin: moa
Selectively prevent glycine release from inhibitory interneurons ➡️ muscle spasms
Vigabatrine: moa
Degradation, inhibits catalysis of GABA by GABA-transaminase
Benzodiazepine, barbiturate, zolpidem
Sedative-hypnotics, acts on GABAa receptor
Gabapentine, tiagabine, vigabatrine
Anticonvulsants, act on GABAa
Muscimol
Hallucinogenic mushroom, acts on GABAa
Picrotoxin, bicuculline
Acts on GABAa receptors
GABAa receptors: mechanism
Open Cl channels, block fast IPSP
Baclofen
Selectively activates GABAb receptors
GABAb receptors: mechanism
Inhibits Ca channels, or activate K channels ➡️ hyperpolarization
Memantine
NMDA antagonist, slows down cell death of memory neurons
Ketamine
Selective blocker of NMDA receptors
Mg2+ site of drug action
Blocks NMDA receptors
Phencyclidine
No therapeutic diseases, cause strong hallucinations
Vesamicol: site of drug action
Blocks vesicular Ach transporter
Tacrine: site of drug action
Act on muscarinic receptors
Phenothiazine, chlorpromazine, haloperidol
Dopamine antagonist, anti-psychotic but can cause Parkinsonian symptoms
Bromocriptine, pergolide
Antiparkinsonism, dopamine agonist
Clonidine, methyldopa
Decrease discharge of sympathetic nerves
