Pharmacogenetics/genomics

Question 1

Pharmacokinetics (4)

Answer 1

Clearance/excretion
Metabolism
Transportation
Absorption

Question 2

Pharmacodynamics (2)

Answer 2

Drug activity

Interact with downstream targets

Question 3

Pharmocogentics

Answer 3

Inherited differences in drug metabolism and response

Question 4

Pharmacogenomics

Answer 4

Use GWAS to assess the impact of SNPs on drug therapy

Question 5

CYP general information (name, location)

Answer 5

Cytochrome p450
Contains heme
Expressed in liver

Question 6

CYP functions to: (2)

Answer 6

Export endogenous and xenobiotic compounds

Activate drugs

Question 7

Drug Metabolism

Answer 7

Phase 1: add hydroxyl group

Phase 2: Function Alize hydroxyl group to increase solubility so it can be excreted

Question 8

Warfarin has jobs include: (3)

Answer 8

Prevent thrombosis
Impair synthesis of clotting factors that are dependent on vitamin K
Inhibit vitamin K epoxide reductase

Question 9

Warfarin’ main job is to:

Answer 9

Find vitamin K and not interact with CYPs in the liver

Question 10

Warfarin’s target is

Answer 10

Vitamin K epoxide reductase (gene is VKORC1)

Question 11

VKORC1 is needed to:

Answer 11

Carboxylate coagulation factors

Question 12

If you inhibit VKORC1 then…..

Answer 12

You can’t regenerate reduced vitamin K

Question 13

By taking warfarin you inhibit ________ which will inhibit __________ and slow down __________

Answer 13

Vitamin K recycling
Recycling of VKORC1
Thrombogenesis

Question 14

Drug tolerance

Answer 14

Need higher dosage to get effect

Question 15

Drug intolerance

Answer 15

Need lower dosage

Also known as drug sensitivity

Question 16

Warfarin is a

Answer 16

BLOOD THINNER