Pharmacodynamics: Lecture 5 Flashcards
Full agonist have a 100%….
Efficacy
What is an example of a full agonist and a partial agonist?
Full: Phenylephrine
Partial: Tolazoline
A full agonist elicits…. response at a concentration…..
Maximal, less than 100
A partial agonist elicits …. responce at a concentration …
Submaximal, greater than 100
What is the difference between fentanyl and morphine?
Fentanyl is more potent than morphine therefore it is only given in a small dose in order to elicit the desired effect
What are chemical antagonists?
This is a substance that binds onto another substance is reduce the effect of the other substance
Adalimamub is a chemical antagonist to….. and it is used as a……
alpha-TNF and it reduces inflammation. It is used as an anti- rheumatic drug
What chemical antagonist is used in treating poisoning?
Dimercarpol, it is a chelating agent that binds onto the metallic substance and decreases the toxicity
Digoxin fragment antibody is a chemical antagonist to …. and what effect does it have?
Digoxin and it neutralises the drug therefore preventing toxicity since digoxin is quite a potent drug
Explain the concept of specificity of drugs?
A drug is not 100% specific to it’s receptor instead it can act on other receptors
Give an example of a drug that does not eilict 100% specificity to the receptor?
Tricyclic anti-depressants are given to block beta adrenergic receptors but instead it can also block muscuranic receptors and histminergic receptors
What does a therapeutic window entail?
It measures the safety of a specific drug
