Pharmacodynamics: Drug Targets Flashcards
What are the drug targets?
- Enzymes
- Ion channels
- Receptors
- Transport proteins
What are the 4 type of receptors?
Type 1: Ligand gated iron
Type 2: G-coupled protein receptors
Type 3: Enzyme linked
Type 4: Intracellular
What is the function of dihydrofolate reductase enzymes?
It is used for the production of purines used in RNA and DNA
What is the function of methotrexate and trimethoprim?
They both serve as anti-cancer drugs. They cause an inhibitory effect on the dihydrofolate reductase enzyme
What is the function of cycloxygenase enzyme?
It serve to catalyse the production of good and bad prostaglandins
What effect do Aspirin and NSAIDs have on the cycloxygenase enzyme?
They have an inhibitory effect
What is the function of HMG- CoA reductase enzyme?
It is the rate determining step that governs the production of cholesterol
Which drugs cause an inhibitory effect on HMG- CoA reductase?
Statins, an example could be simvastatin
What are the agonists and antagonists to beta -adnergic receptors?
Agonist: Noadrenaline/ epinephrine
Antagonist: Propandiol
What are the agonists and antagonists to opiate receptors?
Agonist: Morphine, heroine
Antagonist: Naloxone
In which case can Naloxone be used?
When the patient has overdosed on Heroine
What is a blocker and a modulator of the Na+ gated ion channels?
Blocker: Local anaesthetics
Modulator: Veratidine
What is a blocker and a modulator of GABA gated Cl- ion channels?
Blocker: Picrotoxin
Modulators: Benzodiazepines
Tricycline depressants are used to block which transport proteins?
Noadrenaline Reuptake Transporters
What is a false agonist to Noadrenaline Reuptake Transporter?
Amphetamine
