Pharmacodynamics: Antagonism, Agonism & Allosteric Modulators

Question 1

What are examples of competitive antagonist to agonists?

Answer 1

Propandiol to noadrenaline
Naxolone to morphine
Diprenorphine to etorphine

Question 2

What are the characteristics of competitive antagonism?

Answer 2

• Shift of agonist to the right, meaning increase in demand
• Increase in the IC50
• No change in the Emax

Question 3

What are examples of irreversible antagonist to agonist?

Answer 3

Phenoxybenzime to Noadrenaline or Epinephrine. In cases of patient having Pheochromocytoma. In order to reduce blood pressure

Question 4

What are the characteristics of irreversibe antagonism?

Answer 4

• No change in the IC50

- Decrease in the Emax

Question 5

What are examples of allosteric modulators?

Answer 5

Benzodiazepines on GABA receptors for Diazepam and Midazolam