Pharmacodynamics: Binding

Question 1

What is saturation binding?

Answer 1

Is measures the affinity of the drug to the receptor

Question 2

What is saturation binding depended upon?

Answer 2

Kd- dissociation constant

[ L ]- the concentration of the ligand

Question 3

When is Kd = [L]?

Answer 3

This is [] of the ligand at which 50 % of the receptors are bound therefore Fractional occupancy = 50

Question 4

What is the IC50?

Answer 4

It is a measure of the affinity of the drug to the receptor

Question 5

In which situation is IC50 increased?

Answer 5

This is when the the potency and affinity of the drug are low

Question 6

In which situation is the IC50 decreased?

Answer 6

This is when the potency and affinity of the drug are high therefore a smaller dose of the drug is needed

Question 7

Describe the law of mass action?

Answer 7

If there is an increase in the amount of ligands, therefore there is an increased amount of binding therefore an increased chemical response