Pharmacodynamics

Question 1

Affinity is

Answer 1

• The ability of drug to bind to receptor
• Greater proximity to y-axis the higher affinity
• Inversly related to Kd

Question 2

Potency is

Answer 2

• Relative dose producing affect
• Greater proximity (without crossing) to y-axis the higher

Question 3

Efficacy is

Answer 3

• How well drug produces response
• Maximal hight
• Analog with Vmax

Question 4

Competitive antagonists

Answer 4

• Parallel shift to the right
• Reversed by Increase the dose of agonist
• Appears to decrease potency of the agonist
• Vmax remains the same

Question 5

Noncompetitive antagonists

Answer 5

• Nonparallel shift to the right
• Decrease the efficacy of the agonist
• Decrease Km

Question 6

Examples of intracellular receptors

Question 7

Type 2 HS drugs

Answer 7

1. Penicillin - Hemolytic anemia
2. Methyldopa - Hemolytic anemia
3. Quinidine - Thrombocytopenia
4. Sulfonamide - Granulocytopenia
5. Clozapine - Granulocytopenia

Question 8

Type 3 HS drugs

Answer 8

Cause Vasculitits

1. Sulfonamide
2. Penicillin
3. Thiouracil
4. Lamotrigine
5. Iodines