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Pharmacology > Anti Cancer drugs > Flashcards

Anti Cancer drugs Flashcards

1
Q

Reverse

Pyrimidine antimetabolite that inhibits thymidylate synthetase

A

5-FU mechanism of action

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2
Q

Reverse

Iron-chelating agent preventing the formation of free radicals

A

Dexrazoxane mechanism of action

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3
Q

Reverse

  • Antimetabolite
  • Inhibits DHF reductase (S phase)
A

Methotrexate mechanism of action

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4
Q

Reverse

  • Increase lymphocyte differentitaion and Increase NKs
  • Use in RCC and Metastatic melanoma
A

IL-2 used for

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5
Q

Reverse

  1. Alkylating agents
  2. Antitumor antibiotics
  3. Nitrosoureas
A

Non-cell cycle specific drugs

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6
Q

Reverse

Compleses with Fe and O2 causes DNA strand scission

A

Bleomycin mechanism of action

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7
Q

Reverse

  1. Pneumonitis
  2. Pulmonary fibrosis
A

Bleomycin adverse affects

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8
Q

Reverse

Bleomycin

A

G2 Specific drugs

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9
Q

Reverse

  • Decrease microtubular polymerization
  • Spindle poisons
A

Vinblastine/Vincristine mechanism of action

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10
Q

Reverse

  • Intercalator
  • Forms free radicals
  • Inhibits Topoisomerase
A

Doxorubicin mechanism of action

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11
Q

Reverse

Delayed CHF (give dexrazoxane)

A

Doxorubicin adverse affects

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12
Q

Reverse

  1. BMS
  2. Give Leucovorin for Folinic acid rescue
A

Methotrexate adverse affects

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13
Q

Reverse

Anemias

A

Erythropoietin used for

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14
Q

Reverse

Thrombocytopenia

A

Thrombopoietin used for

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15
Q

Reverse

  • Increase granulocytes
  • Marrow recovery
A

Filgrastim (G-CSF) used for

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16
Q

Reverse

  • Alkylating agent
  • Cross-links DNA strands
A

Cisplatin mechanism of action

17
Q

Reverse

-mustine

A

Nitrosoureas

18
Q

Reverse

  • Alkylating agent
  • Attacks guanine N7 and produces a dysfunctional DNA
A

Cyclophosphamide mechanism of action

19
Q

Reverse

  1. Vinblastine: Blocks tubular polymerization
  2. Vincristine: Blocks tubular polymerization
  3. Paclitaxel: Blocks depolymerization of microtubules
A

M phase specific drugs

20
Q

Reverse

  1. Doxorubicin
  2. Daunorubicin
A

Antitumor antibiotics

21
Q

Reverse

  • Increase granulocytes and macrophages
  • Marrow recovery
A

Sargramostim (GM-CSF) used for

22
Q

Reverse

  1. Increase platelet formation
  2. Used in Thrombocytopenia
A

IL-11 used for

23
Q

Reverse

  1. Cytarabine
  2. 6-mercaptopurine
  3. 6-thioguanine
  4. 5-FU
  5. Methotrexate
  6. Hydroxyurea
A

S phase specific drugs

24
Q

Reverse

Purine antimetabolite that bioactivated by HGPR transferase

A

6-Mercaptopurine mechanism of action

25
Q

Reverse

  1. Cyclophosphamide
  2. Cislplatin
  3. Procarbazine
A

Alkylating agents

26
Q

Reverse

Neurotoxicity

A

Vinblastine/Vincristine adverse affects

27
Q

Reverse

Hemorrhagic cystits (give MESNA)

A

Cyclophosphamide adverse affects

28
Q

Reverse

  1. Nephrotoxicity (give Amifostine)
  2. Neurotoxicity (deafness)
A

Cisplatin adverse affects

Pharmacology (12 decks)

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