Pharmacodynamics Flashcards
Which of the following best describes pharmacodynamics?
a) The study of drug interactions with the body
b) The study of drug effects on the body
c) The study of drug metabolism in the body
d) The study of drug distribution in the body
b) The study of drug effects on the body
Which of the following is NOT a primary mechanism of drug action?
a) Receptor interactions
b) Enzyme interactions
c) Physical interactions
d) Pharmacokinetic interactions
d) Pharmacokinetic interactions
Drugs exert their effects on the body primarily by:
a) Altering genetic makeup
b) Modifying cellular structure
c) Interacting with molecular targets
d) Enhancing organ function
c) Interacting with molecular targets
The therapeutic index of a drug is a measure of its:
a) Efficacy
b) Safety margin
c) Duration of action
d) Absorption rate
b) Safety margin
Which factor can influence the pharmacodynamic response to a drug?
a) Gender
b) Blood type
c) Hair color
d) Shoe size
a) gender
Age-related changes in physiology can affect drug response primarily by:
a) Increasing drug metabolism
b) Decreasing receptor sensitivity
c) Enhancing drug excretion
d) Facilitating drug absorption
b) Decreasing receptor sensitivity
Genetic differences between individuals can impact drug response by affecting:
a) Drug metabolism
b) Drug distribution
c) Drug excretion
d) Drug absorption
a) Drug metabolism
Which of the following is an example of a pharmacodynamic drug interaction?
a) Grapefruit juice inhibiting drug metabolism
b) Antacids reducing drug absorption
c) NSAIDs increasing the risk of bleeding with anticoagulants
d) Antibiotics altering gut flora
NSAIDs increasing the risk of bleeding with anticoagulants
Placebo effects are an example of which factor influencing pharmacodynamics?
a) Genetic variability
b) Psychological factors
c) Disease states
d) Drug interactions
b) Psychological factors
Which of the following is NOT a receptor type involved in pharmacodynamic interactions?
a) G protein-coupled receptors (GPCRs)
b) Enzyme receptors
c) Ligand-gated ion channels
d) Voltage-gated ion channels
b) Enzyme receptors
The phenomenon where prolonged exposure to a drug leads to reduced response over time is known as:
a) Tolerance
b) Sensitization
c) Potentiation
d) Dependence
a) Tolerance
Which term describes the maximal effect a drug can produce, regardless of dose?
a) Potency
b) Efficacy
c) Selectivity
d) Affinity
Answer: b) Efficacy
Which factor is NOT considered when determining a drug’s therapeutic index?
a) Toxicity
b) Efficacy
c) Route of administration
d) Side effects
Answer: c) Route of administration
Which of the following drugs would likely have the narrowest therapeutic index?
a) Warfarin
b) Acetaminophen
c) Ibuprofen
d) Aspirin
a) Warfarin
Which term describes the time required for a drug to elicit a therapeutic response after administration?
a) Onset of action
b) Duration of action
c) Half-life
d) Peak plasma concentration
a) Onset of action