Pharmacodynamics Flashcards
It is the study of what the drug does to our body
Pharmacodynamics
A study of biochemical and physiological effects of the drug on the body
Pharmacodynamics
These are the macromolecules to where the medication binds to
Drug receptors
What is a drug-receptor
target molecules with which a drug molecule has to combine in order to elicit a response
When a drug binds to a receptor, what most likely to happen?
Ion channel will open or close
Biochemical messengers are activated
A normal cellular function is physically inhibited
a cellular function is “turned on”
types of biochemical messengers
cAMP
cGMP
Ca2+
inositol phosphate
Why must a receptor be selective in its ligand characteristics?
It has to be selective so it could elicit a response to a proper chemical signal and not to meaningless ones
These have a high selective affinity for the drug molecule
receptor site or recognition site
these are best-characterized drug receptors
regulatory proteins
Proteins that are considered as drug-receptor
Regulatory proteins enzymes transport proteins structural proteins nucleic acid
which of the following is an example of a receptor that could be classified as an enzyme?
- Na+ k+ ATPase
- tubulin
- dihydrofolate reductase
- NOTA
Dihydrofolate reductase
Na+ k+ ATPase is for transport proteins
tubulin is for structural proteins
Which of the following is true about noncompetitive antagonists?
a. surmountable
b. interact with receptors at a different site as the agonist
c. reversible
d. produced by antagonists that have the ability to activate receptors
Interact with receptors at a different site
These are components of endogenous molecules that bind drug without initiating events leading to any of the drug’s effect
Inert Binding sites
When albumin binds to a receptor but its interaction does not elicit a drug effect is an example of
inert binding sites
this refers to the strength of binding between a drug and its receptor
affinity
examples of inert binding sites
albumin and orosomucoid
it is the transduction process between occupancy of the receptors and drug response
coupling
Which of the class of receptors mediate the actions of hormones?
a. enzymes
b. structural proteins
c. nucleic acid
d. transport
e. regulatory proteins
Regulatory proteins