Antibiotics (Video1) Flashcards
It is an imprecisely applied term, generally used to describe any compound that inhibits the growth of, or actively kills, microorganism
Antibiotics
He was the one who discovered penicillin
Dr. Alexander Fleming
They were the ones who administer first penicillin to human patients
Howard Florey and Ernst Boris Chain
This inhibits bacteria from reproducing but doesn’t kill them
Bacteriostatic
This actively kills the bacteria
Bactericidal
What are the mechanism of antibiotics
- Interferes with the cell wall synthesis or maintenance
- Interferes with nucleic acid synthesis
- Interferes with protein synthesis
These are a collection of diverse enzymes which can cleave the beta-lactam ring, inactivating the antibiotic
Beta-lactamases
Beta-lactamases are commonly produced by
Gram negative bacteria
Situations where bactericidal are preferred over bacteriostatic
- Endocarditis
- Meningitis
- Osteomyelitis
- Neutropenia
Beta-lactams are what type of antibiotics
Bactericidal
These are commonly used antibiotics
Beta-Lactam
What is the mechanism of beta-lactams
They irreversibly inhibiting enzymes that are responsible for the final step in the synthesis of peptidoglycan layer of bacterial cell walls
These are not synthesized but discovered
Natural Penicillin
Aminopenicillin is also called
Penicillinase
Examples of natural penicillin
Benzathine Penicillin and Penicillin G
