Chemotherapeutic Agents Flashcards
It is the prevention or treatment of disease by the use of chemical substances
Chemotherapy
chemically treating an ailment
Chemotherapy
This refers to the synthetic chemical
Chemotherapeutic agents
A generic term referring to either antibiotics or chemotherapeutic agents
antimicrobic or antimicrobial agents
this is a term used to describe all types of antimicrobial agents
antibiotic
This is the ability of a drug to target sites that are relatively specific to the microorganism
selective toxicity
This is a requirement for effective and safe chemotherapy of infections caused by invading organisms
selective toxicity
this is a unique characteristic of antibiotic agents
Selective toxicity
Example of target sites unique to the microorganism
Bacterial cell wall synthesizing enzyme
bacterial ribosomal
the molecular machinery of viral replication
Results of selective toxicity
- Accumulation of drug to higher levels of microorganism than in human cells
- a specific action of a drug on cellular structures that are unique to the microorganism
- actions of drugs on biochemical processes that are more critical to the parasite than to the host
True or False
high selectivity of antibiotics are normally toxic
False
This type of drug is capable of inhibiting the reproduction of the microorganism but does not kill it
Bacteriostatic
True or False
Bactericidal are reversible upon removal
False
bacteriostatic is the type of drug that will be reversible upon removal
Example of drugs that have a bacteriostatic characteristic
erythromycin, sulfonamide, and tetracyclines
this type of drug is dependent on the defense mechanism of the host
Bacteriostatic
This type of drug actively kills the bacteria
Bactericidal
Types of bactericidal
beta-lactam antibiotics and aminoglycosides
This type of drug is less dependent on the defense mechanism of the host for their therapeutic action
Bactericidal
For the treatment of the endocardium and meningitis, what type of drug is more preferred
bactericidal
why is bactericidal preferred in endocardium and meningitis
because the host defenses in this area are relatively ineffective
This is a common practice used to treat tuberculosis
Combination therapy
Bacterial cell walls are formed via?
Biosynthetic pathways
Drugs that inhibit bacterial cell wall synthesis by inhibiting the synthesis of precursors of murein
Cytosine and vancomycin
