Pharma- Toxicities and Drugs

Question 1

Agranulocytosis

Answer 1

Carbamazepine, clozapine

Question 2

Aplastic anemia

Answer 2

Chloramphenicol

Question 3

Cyanide accumulation

Answer 3

Nitroprusside

Question 4

Cycloplegia

Answer 4

Antimuscarinics

Question 5

Date rape

Answer 5

Rohypnol (Flunitrazepam)

Question 6

Diabetes insipidus (nephrogenic)

Answer 6

Lithium

Question 7

Ebstein�s anomaly

Answer 7

Lithium (in pregnancy; disputed)

Question 8

Endometrial CA

Answer 8

Estrogen HRT (prevent by combining with progestin)

Question 9

Fanconi�s syndrome

Answer 9

Expired Tetracyclines

Question 10

�First-dose� syncope

Answer 10

Prazosin

Question 11

Gingival hyperplasia

Answer 11

Phenytoin

Question 12

Gray baby syndrome

Answer 12

Chloramphenicol

Question 13

Monday disease

Answer 13

Nitrates

Question 14

Serotonin syndrome

Answer 14

MAOI and SSRI/Tyramine/Sympathomimetics; muscle rigidity, myoclonus, hyperthermia, CVS instability, seizures (also TCAs, dextrometorphan, meperidine, MDMA, St. John�s wort)

Question 15

Serum sickness

Answer 15

Cefaclor

Question 16

Livor reticularis

Answer 16

Amantadine

Question 17

Lupus-like syndrome

Answer 17

Hydralazine, INH, Procainamide, Phenytoin (HIPP)

Question 18

Methemoglobinemia

Answer 18

Nitrites (not nitrates)

Question 19

Photosensitivity

Answer 19

Sulfonamides, Amiodarone, Tetracycline (SAT)

Question 20

Pseudomembranous colitis

Answer 20

Clindamycin, Ampicillin

Question 21

Pseudotumor cerebri

Answer 21

Tetracycline

Question 22

Pulmonary fibrosis

Answer 22

Amiodarone, Bleomycin, Busulfan

Question 23

Reye syndrome

Answer 23

Aspirin (in children)

Question 24

Thyrotoxicosis

Answer 24

Amiodarone

Question 25

Acute mesenteric ischemia (SMA occlusion)

Answer 25

Digitalis

Question 26

Vaginal Clear Cell CA (in daughters)

Answer 26

Diethylstilbestrol

Question 27

Vertical and horizontal nystagmus

Answer 27

PCP (by extension, Ketamine)

Question 28

Yellow vision

Answer 28

Digitalis