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PBR Fast Review by Cliff > Pharma-Anticancer Drugs Distinctive Toxicities > Flashcards

Pharma-Anticancer Drugs Distinctive Toxicities Flashcards

1
Q

5-FU

A

Photosensitivity; myelosuppression (thymidine rescue)

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2
Q

Bleomycin

A

Pneumonitis, fibrosis; mucocutaneous reactions (alopecia, blisters, hyperkeratosis); hypersensitivity, but minimal myelosuppression

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3
Q

Busulfan

A

Pulmonary fibrosis, hyperpigmentation

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4
Q

Cisplatin

A

Neurotoxic (CN VIII), nephrotoxic

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5
Q

Cyclophosphamide

A

Hemorrhagic cystitis (tx with mesna), SIADH

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6
Q

Cytarabine

A

Cerebellar dysfunction, megaloblastic anemia

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7
Q

Doxorubicin/Daunorubicin

A

Cardiotoxicity (prevent with dexrazoxane)

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8
Q

Mechlorethamine

A

Vesicant, alopecia, sterility

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9
Q

Mercaptopurine

A

Cholestasis, oral and GI ulcers, pancreatitis; metabolism inhibited by allopurinol

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PBR Fast Review by Cliff (22 decks)

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