pharma questions Flashcards

0
Q

what is used in the treatment of hypertensive emergency

A

sodium nitropusside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

what is used to treat diabetes patients w hypertension

A

ACE inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what inhibits NA+ -K+-ATPase and enhances release of intracellular calcium

A

Cardiac glycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What when used with sildenafil can cause dangerous hypotension

A

organic nitrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What inhibits sodium and chloride reabsorption in the ascending loop and early distal tubule

A

thiazide diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

baby aspirin is widely used to reduce the risk of myocardial infarction. what is the mechanism of action of aspirin

A

inhibition of thrmoboxane A2 synthesis in the platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

african american hypertensives respond well to which of the following group of drugs

A

calcium channel blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

beta blockers produce anti-anginal action by which mechanism

A

decreasing myocardial oxygen demand

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which of the heart drugs have low therapeutic index

A

cardiac glycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which of the drug is an aldosterone antagonist and is used in the treatment of advanced cases of heart failure

A

spironolactone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

the antihypertensive drug of choice in pregnancy is

A

methyldopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

which of the following drugs are currently recommended as the first line drug therapy for hypertension unless there are compelling reasons to choose another agent

A

diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

organic nitrates are useful for prevention and treatment of angina. The common side effects of their use are

A

headache and postural hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

irritating dry cough is a well known side effect of which group of drugs

A

thiazide diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which of the following drugs are particularly useful in hypertensive patients w angina or those w migraine

A

b blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

a 42 yo male w an acute MU is treated w thrombolytic drug, streptokinase. what is the mechanism of action of thrombolytic drugs?

A

activation of plasminogen to plasmin

16
Q

clopidegrol is an anti-platelet drug. What is its mechanism of action?

A

inhibition of biding of ADP to its receptors on platelets

17
Q

furosemide is a loop diuretic. it can cause all of the following undesirable effects

A

Hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, hyperglycemia, hyperuricemia, ototoxicity

18
Q

In the treatment of heart failure patients, all of the following group of drugs reduce the cardiac workload:

A

Angiotensin Converting Enzymes (ACE) Inhibitors, Angiotensin II receptor antagonists, direct vasodilators, beta blockers, spironolactone

19
Q

Ketoconazole is an antifungal agent. It is also used in the Tx of:

A

cushing’s syndrome

20
Q

which of the following group of drugs is used in the Tx of hyperprolactinemia?

A

dopamine-receptor agonist

21
Q

the drugs of first choice for Tx of patients w hypercholesterolemia are ___________?

A

HMG-CoA reductase inhibitors

22
Q

amiodarone is a class III anti-arrhythmic drug. What is its mechanism of action?

A

Potassium channel blocker

23
Q

which of the following is a potentially serious complication of long term use of glucocorticoids?

A

Osteoporosis

24
Q

antidote used for warfarin toxicity

A

vit K

25
Q

flushing and pruritus are adverse effects of its use

A

niacin

26
Q

interferes w synthesis of vit K dependent clotting factors

A

warfarin

27
Q

can cause myopathy and rhabdomyolysis

A

HMG-CoA reductase inhibitors

28
Q

long term use can cause osteoporosis

A

glucocorticoids

29
Q

Which of the following drugs inhibits the release of thyroxine from the thyroid gland

A

iodine

30
Q

inhibits peripheral conversion to T4 to T3

A

propylthiuracil

31
Q

used to induce or reinforce labor

A

oxytocin

32
Q

major side effect of all the anticoagulant drugs

A

hemorrhage

33
Q

drug of choice for Tx of hypothyroidism

A

levothyroxine

34
Q

fludrocortisone is a steroid drug w potent mineralocorticoid activity. what is true of mineralocorticoid drugs

A

involved in salt and water balance

35
Q

erthropoietin is used to treat

A

anemia in end stage renal failure

36
Q

39 pregnant female requires heparin to prevent intravascular clot formation. what is the MOA

A

binding of antithrobin to something