Antimicrobial Drugs - Cephalosporins etc

Question 1

There are four generations of Cephalosporins. What are the details of the first?

Answer 1

narrow spectrum, sensitive to beta-lactamase: Cefazolin

Question 2

There are four generations of Cephalosporins. What are the details of the second?

Answer 2

broader gram negative activity: cefoxitin

Question 3

There are four generations of Cephalosporins. What are the details of the third?

Answer 3

broad spectrum, resistant to most cephalosporinases: Ceftriaxone, cefotaxime

Question 4

There are four generations of Cephalosporins. What are the details of the fourth?

Answer 4

cefapime

Question 5

What is the first line drug in the Txof gonorrhea?

Answer 5

ceftriaxone, thrid generation cephalosporin

Question 6

What drug is used in the Tx of meningitis in children bc of its effectiveness against hemophyllus influenzae?

Answer 6

ceftriaxone

Question 7

What does Vancomycin treat?

Answer 7

drug of choice for the Tx of methicillin-resistant Staphylococcus Aureus- MRSA

Question 8

What is the main u/e symptom of Vancomycin?

Answer 8

flushing and shock result due to histamine release caused by rapid infusion. Dose related ototoxicity can occur in patients w renal failure.

Question 9

What is the MOA of cell membrane active agent, Daptomycin?

Answer 9

induces rapid depolarization of bacterial cytoplasmic membrane and disrupts multiple aspects of membrane Fx and inhibits synthesis of DNA, RNA and protein.

Question 10

What is Daptomycin indicated for?

Answer 10

complicated skin infections and bacteremia caused by s. aureus.