Pharm4 Flashcards
Sympathetic Receptor:
- a1
G-Protein Class: q
Sympathetic Receptor:
- a2
G-Protein Class: i
Sympathetic Receptor:
- ß1
G-Protein Class: s
Sympathetic Receptor:
- ß2
G-Protein Class: s
Parasympathetic receptor:
- M1
G-Protein Class: q
Parasympathetic receptor:
- M2
G-Protein Class: i
Parasympathetic receptor:
- M3
G-Protein Class: q
Dopamine receptor:
- D1
G-Protein Class: s
Dopamine receptor:
- D2
G-Protein Class: i
Histamine receptor:
- H1
G-Protein Class: q
Histamine receptor:
- H2
G-Protein Class: s
Vasopressin receptor:
- V1
G-Protein Class: q
Vasopressin receptor:
- V2
G-Protein Class: s
Function:
- a1
INCREASED:
- vascular smooth muscle contraction
- pupillary dilator muscle contraction (mydriasis)
- intestinal & bladder sphincter contraction
Function:
- a2
DECREASED:
- sympathetic outflow
- insulin release
- lipolysis
INCREASED:
- platelet aggregation
Function:
- ß1
INCREASED:
- heart rate
- contractility
- renin release
- lipolysis
Function:
- ß2
Vasodilation Bronchodilation Ciliary muscle relaxation INCREASED: - heart rate - contraction - lipolysis - insulin release - aqueous humor production DECREASED: - uterine tone (tocolysis)
Function:
- M1
CNS, enteric nervous system
Function:
- M2
DECREASED:
- heart rate
- contractility of Atria
Function:
- M3
INCREASED:
- exocrine gland secretions
- gut peristalsis
- bladder contraction
- bronchoconstriction
- pupillary sphincter muscle contraction (miosis)
- ciliary muscle contraction (accomodation)
Function:
- D1
Relaxes renal vascular smooth muscle
Function:
- D2
Modulates transmitter release, especially in brain
Function:
- H1
Contraction of bronchioles Pruritis Pain INCREASED: - nasal & bronchial mucus production
Function:
- H2
INCREASED:
- gastric acid secretion
Function:
- V1
INCREASED:
- vascular smooth muscle contration
Function:
- V2
INCREASED:
- H20 permeability and reabsorption in the Collecting tubules of kidney
“V2 is found in the 2 kidneys”
