Pharm3

Question 1

Zero-order elimination.

Answer 1

Rate of elimination is CONSTANT regardless of Cp.

Cp Decreases linearly with time

Question 2

What are examples of Zero-order drugs?

Answer 2

“PEA”
Phenytoin
Ethanol
Aspirin

Question 3

First-order elimination.

Answer 3

Rate of elimination is Directly Proportional to drug concentration.

Cp decreases exponentially with time

Question 4

Efficacy.

Answer 4

Maximal effect a drug can produce

Question 5

Potency.

Answer 5

Amount of drug needed for give effect

INcreased Potency = INcreased affinity for receptor

Question 6

What are High-Efficacy drug classes?

Answer 6

Analgesics
Antibiotics
Antihistamines
Decongestants

Question 7

What are Highly-Potent drug classes?

Answer 7

Chemotherapeutic
Antihypertensive drugs
Antilipid drugs

Question 8

Measurement of drug safety is called?

Answer 8

Therapeutic index

Question 9

Therapeutic Index (IE) =

Answer 9

= LD50/ED50

LD50 = median lethal dose

ED50 = median effective dose

Question 10

Do safer drugs have a higher or lower IE?

Answer 10

Higher

Question 11

What are some drugs with a Low IE?

Answer 11

Digoxin
Lithium
Theophylline
Warfarin

Question 12

Measurement of clinical drug safety is called?

Answer 12

Therapeutic window

Range of minimum effective dose to minimum toxic dose