Pharm2

Question 1

Fraction of administered drug that reaches systemic circulation unchanged is called?

Answer 1

Bioavailability (F)

IV dose = 100%

Question 2

Theoretical fluid volume required to maintain the total absorbed drug amount at the plasma concentration is called?

Answer 2

Volume of Distribution (Vd)

Question 3

Volume of distribution (Vd) equation.

Answer 3

Vd = (amount of drug in body/plasma drug concentration)

Question 4

Half-life (t1/2)

Answer 4

t1/2 = (0.7 x Vd) / CL

Question 5

Half-life is a property of what type of elimination?

Answer 5

First order

Question 6

What relates the rate of elimination to the plasma concentration?

Answer 6

Clearance (CL)

Question 7

Clearance (CL) equation.

Answer 7

CL = (rate of elimination of drug/plasma drug concentration)

= Vd X Ke (elimination constant)

Question 8

Loading dose =

Answer 8

= Cp X Vd/F

Cp = target plasma concentration

Question 9

Maintenance dose =

Answer 9

= Cp X CL/F

Cp = target plasma concentration

Question 10

What happens to the maintenance dose and loading dose in Renal or Liver disease?

Answer 10

Maintenance dose - DEcreases

Loading dose - Unchanged