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OS Pulmonary > Pharm--TB Drugs > Flashcards

Pharm--TB Drugs Flashcards

1
Q

Isoniazid MOA

A

Inhibit cell wall synthesis - mycolic acid synthesis; cidal for rapid dividers and static for slow growing

Works for intracellular bc penetrates host cells

Never use INH as a single agent in ACTIVE TB.

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2
Q

Ethambutol MOA

A

Inhibit cell wall synthesis - disrupts arabinogalactan synthesis

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3
Q

Pyrazinamide MOA

A

Disrupts PM and energy metabolism - conversion to metabolite decreases cell pH

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4
Q

Rifampin

A

Inhibit RNA synthesis by binding RNA pol

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5
Q

Thinking of INH ADME, you worry about…

A

Chronic liver disease - needs dose reduction

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6
Q

INH AEs

A

Peripheral neuropathy; hepatotoxicity (2%) due to toxic metabolite

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7
Q

INH interactions

A

Antacids with Al; inhibitor of P450

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8
Q

INH supplement with what and why

A

Vit. B6 to prevent peripheral neuropathy

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9
Q

Rifampin cidal static?

A

Cidal

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10
Q

Rifampin excretion

A

bile

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11
Q

Rifampin AEs

A

Makes body fluids orange-red
Hepatotoxic
Induces P450

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12
Q

What are some other uses for rifampin besides TB?

A

MRSA, meningitis prophyl from H flu; staph in carriers

Antileprosy

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13
Q

Ethambutol cidal static?

A

Concentration dep

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14
Q

Ethambutol ADME note

A

reduce dose in renal disease

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15
Q

Ethambutol AE

A

Loss of color discrimination (optic neuritis) - dose related

Hyperuricemia

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16
Q

Ethambutol interactions

A

Al+ antacids

17
Q

Pyrazinamide cidal static?

A

dep on conc

18
Q

This one is a prodrug

A

pyrazinamide

19
Q

Pyrazinamide AEs

A

Dose-related hepatotoxicity - cumulative
Hyperuricemia
Arthralgia

20
Q

Cycloserine MOA

A

Block cell wall synthesis / structural analog of D-Ala

21
Q

Cycloserine ADME ..

A

Dose adjustment for renal

22
Q

Cycloserine AEs

A

CNS - HA, tremor, confusion, psychosis and suicidal tendencies, seizures

23
Q

Cycloserine C/I

A

seizures

24
Q

What drugs are used for XDR?

A

FQs, and at least one of: amikacin, kanamycin, or capreomycin

OS Pulmonary (13 decks)

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