Pharm--Lung Cancer

Question 1

What is the treatment approach to SCLC?

Answer 1

Metastasis occurs early, so chemotherapy + radiation is the only option

Question 2

What is the treatment approach in NSCLC?

Answer 2

Surgical resection unless metastasis has occurred

Question 3

What is the standard treatment for SCLC?

Answer 3

Etoposide

Cisplatin or carboplatin

Question 4

What is the standard streatment for NSCLC?

Answer 4

Cisplatin + 1 of many others

Question 5

Cisplatin MOA

Answer 5

DNA crosslinker

Question 6

Gemcitabine MOA

Answer 6

DNA pol inhibitor by introducing bogus triphosphate

Question 7

Paclitaxel MOA

Answer 7

Microtubule stabilizer prevents polymerization

Question 8

Pemetrexed MOA

Answer 8

DHFR inhibitor

Question 9

Bevacizumab MOA

Answer 9

VEGF inhibitor

Question 10

Critzotinib MOA

Answer 10

TKI, anti-ALK

Question 11

Erlotinib MOA

Answer 11

TKI, anti-EGFR

Question 12

Doxorubicin MOA

Answer 12

Intercalation
Free radical generation (cardiotoxic)
Topo II inhibitor

Question 13

MTX MOA

Answer 13

DHFR inhibitor

Question 14

Topotecan MOA

Answer 14

DNA topo I stabilizer

Question 15

Carboplatin MOA

Answer 15

DNA Crosslinks

Question 16

Ifosfamide MOA

Answer 16

Intra/interstrand crosslinks

Question 17

Cyclophosphamide MOA

Answer 17

Prodrug alkylating agent

Question 18

Vincristine MOA

Answer 18

Microtubule inhibitor

Question 19

Carboplatin AEs

Answer 19

Dose-limiting myelosuppression

Question 20

Cisplatin AEs

Answer 20

RENAL -> monitor!

myelosuppression

Question 21

Cyclophosphamide AEs

Answer 21

myelosuppression
Hemorrhagic cystitis (use MESNA)
Pulmonary fibrosis
Infertility

Question 22

Doxorubicin AEs

Answer 22

Neutropenia (myelosuppression)

Heart toxicity

Question 23

Gemcitabine AEs

Answer 23

Myelosuppression
Arthralgia, fatigue
Sensory neuropathy

Question 24

Ifosfamide AEs

Answer 24

Myelosuppression
Hematuria renal failure
neurotoxicity

Question 25

Paclitaxel AEs

Answer 25

Myelosuppression Taxane hypersensitivity Myalgia/arthralgia

Question 26

Pemetrexed AEs

Answer 26

myelosuppression | GI, esp w/ cisplatin

Question 27

Topotecan AEs

Answer 27

Myelosupression GI Hyperbilirubinemia

Question 28

Vincristine AEs

Answer 28

Myelosuppression Neuropathy GI

Question 29

Erlotinib AEs

Answer 29

Diarrhea Interstitial lung events Corneal perforation RASH!!

Question 30

TKI resistance

Answer 30

Tumor closes off ATP binding pocket

Question 31

Crizotinib AEs

Answer 31

GI N/V common Edema 28% Visual disorders ~62%

Question 32

Bevacizumab AEs

Answer 32

Hypertension | **Hemorrhage-can be life-threatening!

Question 33

For which lung cancer should you never give Bevacizumab?

Answer 33

Squamous (near vessels)