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OS Pulmonary > Pharm--Lung Cancer > Flashcards

Pharm--Lung Cancer Flashcards

1
Q

What is the treatment approach to SCLC?

A

Metastasis occurs early, so chemotherapy + radiation is the only option

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2
Q

What is the treatment approach in NSCLC?

A

Surgical resection unless metastasis has occurred

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3
Q

What is the standard treatment for SCLC?

A

Etoposide

Cisplatin or carboplatin

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4
Q

What is the standard streatment for NSCLC?

A

Cisplatin + 1 of many others

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5
Q

Cisplatin MOA

A

DNA crosslinker

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6
Q

Gemcitabine MOA

A

DNA pol inhibitor by introducing bogus triphosphate

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7
Q

Paclitaxel MOA

A

Microtubule stabilizer prevents polymerization

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8
Q

Pemetrexed MOA

A

DHFR inhibitor

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9
Q

Bevacizumab MOA

A

VEGF inhibitor

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10
Q

Critzotinib MOA

A

TKI, anti-ALK

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11
Q

Erlotinib MOA

A

TKI, anti-EGFR

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12
Q

Doxorubicin MOA

A

Intercalation
Free radical generation (cardiotoxic)
Topo II inhibitor

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13
Q

MTX MOA

A

DHFR inhibitor

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14
Q

Topotecan MOA

A

DNA topo I stabilizer

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15
Q

Carboplatin MOA

A

DNA Crosslinks

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16
Q

Ifosfamide MOA

A

Intra/interstrand crosslinks

17
Q

Cyclophosphamide MOA

A

Prodrug alkylating agent

18
Q

Vincristine MOA

A

Microtubule inhibitor

19
Q

Carboplatin AEs

A

Dose-limiting myelosuppression

20
Q

Cisplatin AEs

A

RENAL -> monitor!

myelosuppression

21
Q

Cyclophosphamide AEs

A

myelosuppression
Hemorrhagic cystitis (use MESNA)
Pulmonary fibrosis
Infertility

22
Q

Doxorubicin AEs

A

Neutropenia (myelosuppression)

Heart toxicity

23
Q

Gemcitabine AEs

A

Myelosuppression
Arthralgia, fatigue
Sensory neuropathy

24
Q

Ifosfamide AEs

A

Myelosuppression
Hematuria renal failure
neurotoxicity

25
Q

Paclitaxel AEs

A

Myelosuppression
Taxane hypersensitivity
Myalgia/arthralgia

26
Q

Pemetrexed AEs

A

myelosuppression

GI, esp w/ cisplatin

27
Q

Topotecan AEs

A

Myelosupression
GI
Hyperbilirubinemia

28
Q

Vincristine AEs

A

Myelosuppression
Neuropathy
GI

29
Q

Erlotinib AEs

A

Diarrhea
Interstitial lung events
Corneal perforation
RASH!!

30
Q

TKI resistance

A

Tumor closes off ATP binding pocket

31
Q

Crizotinib AEs

A

GI N/V common
Edema 28%
Visual disorders ~62%

32
Q

Bevacizumab AEs

A

Hypertension

**Hemorrhage-can be life-threatening!

33
Q

For which lung cancer should you never give Bevacizumab?

A

Squamous (near vessels)

OS Pulmonary (13 decks)

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