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Bioscience > Pharm Quiz > Flashcards

Pharm Quiz Flashcards

1
Q

Within the scope of pharmacotherapeutics, what are specific drugs most often used for?

  1. Prevention
  2. Treatment
  3. Diagnosis of disease
A

Treatment

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2
Q

The quantitative, time-dependent changes of both plasma drug concentration and the total amount of drug in the body, following the the drug’s administration by various routes is defined by:

  1. Pharmacodynamics
  2. Pharmacokinetics
A

Pharmacokinetics

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3
Q

Where is the drug found after it is absorbed?

  1. Site of administration
  2. Plasma
  3. Tissue
  4. Bile
A

Plasma

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4
Q

Route of drug administration is dependent on all of the following except:

  1. Solubility
  2. Ionization
  3. Speed of action desired
  4. Concentration Gradient
  5. Action (systemic or local)
A

Concentration Gradient

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5
Q

Water soluble drugs should be taken

  1. Enterally
  2. Parenterally
A

Parenterally. It would not be able to cross the phospholipid bilayer and be absorbed by the GI tract

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6
Q

Formula for bioavailability

A

Plasma Concentration/Dose

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7
Q

When administering drugs enterally under the tongue (sublingual), where does the drug drain into?

  1. Arteries
  2. Lymph Nodes
  3. Veins
  4. All of the above
A

Veins (of the face and neck, enter the inferior vena cava)

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8
Q

There is a large vascular network available in oral and rectal mucosa

  1. True
  2. False
A

True

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9
Q

In order for a drug to be absorbed by the GI tract, it needs to have what 2 credentials?

A

Lipid Soluble and Neutral

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10
Q

Nitro glycerine is usually taken

  1. Parenterally
  2. Enterally
A

Enterally. However, due to first-pass effect, 90% is broken down by liver. Therefore, it should be taken sublingually

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11
Q

All of the following are forms of parenteral administration except:

  1. Intravenous
  2. Intramuscular
  3. Subcutaneous (insulin pump)
  4. Into bone
A

Into bone

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12
Q

Good control of delivered dose is seen with

  1. Enteral administration
  2. Parenteral Administration
A

Parenteral

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13
Q

With parenteral administration, there is limited drug delivery for which 2 entryways?

A

Intramuscular and Subcutaneous

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14
Q

What is the second most rapid form of drug administration after parenteral entry?

  1. Enteral
  2. Inhalation
  3. Intranasal
  4. Intrathecal
A

Inhalation (alveolar space into circulatory system). However, it is complicated for self-delivery.

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15
Q

Chemotherapy is usually administered:

  1. Intranasal
  2. Intrathecal
  3. Topically
  4. Transdermal
A

Intrathecal (into subarachnoid space)

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16
Q

Iontophoresis refers to

  1. Ultrasound
  2. Electrical Current
A

Electrical Current. Phonophoresis refers to ultra sound.

17
Q

Non-vascular tissues and plasma proteins cannot take up or bind drugs

  1. True
  2. False
A

False

18
Q

All of the following organs are included in the vessel rich group except for:

  1. Spleen
  2. Kidney
  3. Liver
  4. Lungs
A

Spleen

19
Q

Low volume of distribution would imply that a drug is:

  1. Water soluble and contained within plasma
  2. Do lots of things, readily distributed to other compartments, have many more side effects
A

Water soluble and contained within plasma

20
Q

How many liters marks the “average” for Vd

A

42 Liters (distributed uniformly). 42=high Vd

21
Q

All of the following are sites for drug metabolism except:

  1. Liver
  2. Kidneys
  3. Lungs
  4. Heart
  5. Skin
  6. GI tract
A

Heart

22
Q

When a drug goes from being an unexcretable drug to excretable metabolite, it is going to become

  1. water soluble
  2. Non-water soluble
A

water soluble

23
Q

The product of biotransformation is:

A

metabolite

24
Q

Chemical modification occurs in all of the following ways except:

  1. Anabolism
  2. Oxidation
  3. Reduction
  4. Hydrolysis
A

Anabolism

25
Q

What is the most common pathway for oxidation during phase 1 metabolism?

A

Cytochrome P450 (cyp3A4 for liver)

26
Q

Which of the following does not occur within phase 2 of a metabolic pathway?

  1. Chemical modification
  2. Conjugation of drug to form a large, polar molecule
  3. Enhancement of solubility and excretion in urine or bile
A

Chemical modification

27
Q

Drugs that have a short half-life are more detrimental to health than drugs that have a long half-life

  1. True
  2. False
A

False

28
Q

Aging and enzyme-induction are associated with:

  1. Decreasing Half-Life
  2. Increasing Half-Life
A

Decreasing half-life

29
Q

Prolonged increase in stimulation will lead to decrease in receptor function

  1. True
  2. False
A

True

30
Q

What is the most common form of drug interaction among humans?

  1. ion channel
  2. G-protein couples
  3. Enzyme Coupled
  4. Intra-cellular
A

G-Protein Coupled

31
Q

The magnitude of the response that can be achieved refers to:

  1. Efficacy
  2. Potency
A

Efficacy

32
Q

The higher the therapeutic index is, the safer the medication

  1. True
  2. False
A

True

33
Q

What is the third step in the clinical decision making prcoess:

  1. Perform a medical reconciliation
  2. Look for links between the patient’s signs and symptoms and meds using a systems-based approach
  3. Modify the treatment plan based on safety concerns introduced by medications
  4. Identify patient risk factors for an adverse drug reaction
A

Look for links between the patient’s signs and symptoms and meds using a systems-based approach

Bioscience (6 decks)

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