Pharm Quiz

Question 1

Within the scope of pharmacotherapeutics, what are specific drugs most often used for?

1. Prevention
2. Treatment
3. Diagnosis of disease

Answer 1

Treatment

Question 2

The quantitative, time-dependent changes of both plasma drug concentration and the total amount of drug in the body, following the the drug’s administration by various routes is defined by:

1. Pharmacodynamics
2. Pharmacokinetics

Answer 2

Pharmacokinetics

Question 3

Where is the drug found after it is absorbed?

1. Site of administration
2. Plasma
3. Tissue
4. Bile

Answer 3

Plasma

Question 4

Route of drug administration is dependent on all of the following except:

1. Solubility
2. Ionization
3. Speed of action desired
4. Concentration Gradient
5. Action (systemic or local)

Answer 4

Concentration Gradient

Question 5

Water soluble drugs should be taken

1. Enterally
2. Parenterally

Answer 5

Parenterally. It would not be able to cross the phospholipid bilayer and be absorbed by the GI tract

Question 6

Formula for bioavailability

Answer 6

Plasma Concentration/Dose

Question 7

When administering drugs enterally under the tongue (sublingual), where does the drug drain into?

1. Arteries
2. Lymph Nodes
3. Veins
4. All of the above

Answer 7

Veins (of the face and neck, enter the inferior vena cava)

Question 8

There is a large vascular network available in oral and rectal mucosa

1. True
2. False

Answer 8

True

Question 9

In order for a drug to be absorbed by the GI tract, it needs to have what 2 credentials?

Answer 9

Lipid Soluble and Neutral

Question 10

Nitro glycerine is usually taken

1. Parenterally
2. Enterally

Answer 10

Enterally. However, due to first-pass effect, 90% is broken down by liver. Therefore, it should be taken sublingually

Question 11

All of the following are forms of parenteral administration except:

1. Intravenous
2. Intramuscular
3. Subcutaneous (insulin pump)
4. Into bone

Answer 11

Into bone

Question 12

Good control of delivered dose is seen with

1. Enteral administration
2. Parenteral Administration

Answer 12

Parenteral

Question 13

With parenteral administration, there is limited drug delivery for which 2 entryways?

Answer 13

Intramuscular and Subcutaneous

Question 14

What is the second most rapid form of drug administration after parenteral entry?

1. Enteral
2. Inhalation
3. Intranasal
4. Intrathecal

Answer 14

Inhalation (alveolar space into circulatory system). However, it is complicated for self-delivery.

Question 15

Chemotherapy is usually administered:

1. Intranasal
2. Intrathecal
3. Topically
4. Transdermal

Answer 15

Intrathecal (into subarachnoid space)

Question 16

Iontophoresis refers to

1. Ultrasound
2. Electrical Current

Answer 16

Electrical Current. Phonophoresis refers to ultra sound.

Question 17

Non-vascular tissues and plasma proteins cannot take up or bind drugs

1. True
2. False

Answer 17

False

Question 18

All of the following organs are included in the vessel rich group except for:

1. Spleen
2. Kidney
3. Liver
4. Lungs

Answer 18

Spleen

Question 19

Low volume of distribution would imply that a drug is:

1. Water soluble and contained within plasma
2. Do lots of things, readily distributed to other compartments, have many more side effects

Answer 19

Water soluble and contained within plasma

Question 20

How many liters marks the “average” for Vd

Answer 20

42 Liters (distributed uniformly). 42=high Vd

Question 21

All of the following are sites for drug metabolism except:

1. Liver
2. Kidneys
3. Lungs
4. Heart
5. Skin
6. GI tract

Answer 21

Heart

Question 22

When a drug goes from being an unexcretable drug to excretable metabolite, it is going to become

1. water soluble
2. Non-water soluble

Answer 22

water soluble

Question 23

The product of biotransformation is:

Answer 23

metabolite

Question 24

Chemical modification occurs in all of the following ways except:

1. Anabolism
2. Oxidation
3. Reduction
4. Hydrolysis

Answer 24

Anabolism

Question 25

What is the most common pathway for oxidation during phase 1 metabolism?

Answer 25

Cytochrome P450 (cyp3A4 for liver)

Question 26

Which of the following does not occur within phase 2 of a metabolic pathway? 1. Chemical modification 2. Conjugation of drug to form a large, polar molecule 3. Enhancement of solubility and excretion in urine or bile

Answer 26

Chemical modification

Question 27

Drugs that have a short half-life are more detrimental to health than drugs that have a long half-life 1. True 2. False

Answer 27

False

Question 28

Aging and enzyme-induction are associated with: 1. Decreasing Half-Life 2. Increasing Half-Life

Answer 28

Decreasing half-life

Question 29

Prolonged increase in stimulation will lead to decrease in receptor function 1. True 2. False

Answer 29

True

Question 30

What is the most common form of drug interaction among humans? 1. ion channel 2. G-protein couples 3. Enzyme Coupled 4. Intra-cellular

Answer 30

G-Protein Coupled

Question 31

The magnitude of the response that can be achieved refers to: 1. Efficacy 2. Potency

Answer 31

Efficacy

Question 32

The higher the therapeutic index is, the safer the medication 1. True 2. False

Answer 32

True

Question 33

What is the third step in the clinical decision making prcoess: 1. Perform a medical reconciliation 2. Look for links between the patient's signs and symptoms and meds using a systems-based approach 3. Modify the treatment plan based on safety concerns introduced by medications 4. Identify patient risk factors for an adverse drug reaction

Answer 33

Look for links between the patient's signs and symptoms and meds using a systems-based approach