pharm on nsaids and steroids

Question 1

for non-opioid analgesics we have a ceiling effect for what?

Answer 1

analgesia

Question 2

acetominophen an anti-inflammatory drug?

Answer 2

nope

Question 3

Aspirin inhibits

Answer 3

cyclooxygenase; there is a irreversible inhibition of thromboxane formation

Question 4

reye’s syndrome

Answer 4

occurs when children take aspiring with a viral illness especially varicella

Question 5

aspirin and tinnitus

Answer 5

it occurs when aspiring is taken too frequently

Question 6

NSAIDs MOA

Answer 6

inhibition of cyclooxygenase; the effect on thromboxane is reversible

Question 7

reduced risk of ulceration if NSAIDs taken with food?

Answer 7

nope, the effect on prostaglandins is systemic

Question 8

prostaglandins promote ______ of the muscles

Answer 8

contraction

Question 9

misoprostol MOA

Answer 9

prostaglandin E1 analogue can lead to diarrhea and abd. pain and it can also caused abortion of a fetus since prostaglandins promote contraction

Question 10

what can be given to NSAIDs or aspiring to reduce the GI risk for ulcers

Answer 10

either by giving them misoprostol or a PPI

Question 11

celecoxib

Answer 11

COX-2 specific inhibitors less specific vs refocoxib

Question 12

Celecoxib in difference to NSAIDs side effects

Answer 12

less GI toxicity but increase in cardiovascular-related adverse events due to the theory of disruption in balance between prostacyclin and thromboxane

Question 13

Acetaminophen MOA

Answer 13

unknown

Question 14

Acetaminophen SE

Answer 14

usually very well tolearted but can lead to hepatotoxic and there is a hypothetical interaction with warfarin ( increased risk for hemorrhage)

Question 15

N-acetylcysteine MOA

Answer 15

Neutralizes NAPQI toxic metabolite

Question 16

cortisol increases annexin-1 production which leads to

Answer 16

an inhibition of the production of arachidonic acid

Question 17

Highest amount of GC activity leads to stronger ____________ effects

Answer 17

anti-inflammatory

Question 18

corticosteroids ocular tox

Answer 18

cataracts