osteoarthritis

Question 1

Most common form of arthritis

Age-related

Answer 1

OA

Question 2

OA is characterized by damage to ligaments and cartilaginous structures accompanied by compensatory and pathological changes in the surrounding bone

Answer 2

OA is characterized by damage to ligaments and cartilaginous structures accompanied by compensatory and pathological changes in the surrounding bone

Question 3

OA affects what joints

Answer 3

the weight baring joints

Question 4

OA detected by x-ray is often __________

Answer 4

asymptomatic

Question 5

Major Risk factors (6)

Answer 5

1. age
2. BMI
3. joint injury
4. heritability
5. heavy (injurious) joint use
6. estrogen withdrawal

Question 6

symptoms of OA (5)

Answer 6

1. pain- static
2. stiffness- morning
3. mechanical symptoms- instability
4. swelling
5. crepitus

Question 7

what type of bone swelling do we see in OA

Answer 7

1. heberden nodes

2. bouchard nodes

Question 8

soft tissue swelling in OA?

Answer 8

yep we see effusions and synovitis (non-inflammatory)

Question 9

OA as multistructural failure with cartilage damage (3) bone pathology (4) and biomechanical disorder that all could lead to joint failure

Answer 9

cartilage damage:

1. meniscal
2. hyaline
3. labrum (hip)

Bone pathology:

1. osteophytes
2. sclerosis
3. cysts
4. bone marrow lesions

Question 10

role of biomechanics (2 paths)

Answer 10

1. . abn. loading but normal tissues- overweight

2. normal loading but abn. tissues- injury

Question 11

hyaline cartilage is made of what type of collagen?

Answer 11

type II collagen– aggrecan

Question 12

chondrocytes are (3)

Answer 12

1. terminally differentiated
2. metabolically active
3. limited capacity for repair

Question 13

Osteoarthritic chondrocytes are __________ reflecting increased metabolic activity

Answer 13

hyperplastic

Question 14

Collagen degradation
Proteoglycan loss
Edema
Hyperplastic chondrocytes

Answer 14

OA cartilage

Question 15

Avascular Chondrocytes:
 terminally differentiated
 maintain steady state
 glucose main energy source
 cartilage turnover is slow

Answer 15

normal cartilage

Question 16

Bone in OA

1. Force impact leads to
2. trabecular

Answer 16

1. Force impact leads to dispersion

2. trabecular disruption

Question 17

associated with knee pain
Responsive to intervention
Predict progression of cartilage damage

Answer 17

BMLs

Question 18

Inflammation OA

Answer 18

not systemic but there is some local inflammation…

** RA is systemic inflammation

Question 19

Inflammation in Knee OA:

1. Effusion / synovial swelling on MRI; correlates with ____
2. Synovial biopsies
3. histology correlates with cartilage ______
4. cytokines

Answer 19

1. Effusion / synovial swelling on MRI; correlates with pain
2. Synovial biopsies: Cartilage fragments -> synovial cell, chondrocyte reaction-> MMPs
3. histology correlates with cartilage damage
4. IL-1, IL-7, TNFα

Question 20

OA treatment (2)

Answer 20

1. exercise

2. weight loss

Question 21

surgical treatment of OA

Answer 21

joint replacement (arthroplasty)

Question 22

___________ is the process by which biomechanical signals regulate cell activity and behavior.

Answer 22

Mechanotransduction

Question 23

OA treatment pathways pharm

Answer 23

topical NSAIDs