fibromyalgia

Question 1

Fibromyalgia is a syndrome characterized by (3) . May occur in patients with an underlying chronic disease: RA, SLE, osteoarthritis, Lyme disease, HIV, sleep apnea. _____ predominance
and onset between _______ years old. In more than half of patients, symptoms preceded by _____________

Answer 1

diffuse pain, stiffness, and fatigue

Female predominance
and onset between 20-60 years old. In more than half of patients, symptoms preceded by physical or emotional stress or flu-like illness

Question 2

how is the clinical features of fibromyalgia?

Answer 2

diffuse pain that is chronic and migratory. Head to toe. they also have stiffness in the morning , sweling in hands and some paresthesias but symptoms vary day by day

Question 3

fibromyalgia cognitive difficulties

Answer 3

Fibro- fog–> difficulty in concentrating

Question 4

how is the sleep with fibromyalgia?

Answer 4

horrible no good rest

Question 5

drug issues with fribromyalgia?

Answer 5

yep, a lot of allergic symptoms

Question 6

tender point in fribromyalgia

Answer 6

9!!!!

Examination reveals soft-tissue tender points. Laboratory testing is normal and should be kept to a minimum

Question 7

In more than half of patients, symptoms preceded by physical or emotional stress or flu-like illness

Answer 7

classification of fibromyalgia but we have moved on from this and it is now more inclusive

Question 8

Fibromyalgia-pathophysiology

Answer 8

we have no idea but there is some genetic predisposition but what we do know is that there is Abnormalities in central pain processing with heightened pain sensitivity

Question 9

5-HT2A receptor polymorphism T/T phenotype2
Serotonin transporter3
Dopamine D4 receptor exon III repeat polymorphism4
COMT (catecholamine o-methyl transferase)5
Heterozygous beta-3 adrenergic receptor allele6

Answer 9

all genes that might cause fibromyalgia

Question 10

Patients display a _____________“detection threshold” to sensory stimuli, but exhibit a __________ “noxious threshold”. This is not just to pressure, but also to other stimuli, e.g., heat, noise, electrical stimulation. This phenomenon is independent of psychological factors such as expectancy or hypervigilance

Answer 10

display a normal “detection threshold” to sensory stimuli, but exhibit a decreased “noxious threshold”. This is not just to pressure, but also to other stimuli, e.g., heat, noise, electrical stimulation. This phenomenon is independent of psychological factors such as expectancy or hypervigilance

Question 11

_______Influences on Nociceptive Processing

Answer 11

Supraspinal

Question 12

Abnormalities of neurochemicals that integrate pain, sleep and mood thought to play an important role:

1. Serotonin in blood ___________ in subset of patients

2, Substance P ___________ in cerebrospinal fluid of patients

Answer 12

1. Serotonin in blood decreased in subset of patients

2, Substance P elevated in cerebrospinal fluid of patients

Question 13

Fibromyalgia and neuroendocrine dynsfunction

Answer 13

anb. in the hypothalamic-adrenal axis abn. with relative adrenal hyporesponsiveness and there are some growth hormones changes in regulation

Question 14

In Fibromyalgia, we see abnormal wave pattern seen on EEG in stage

Answer 14

3-4 deep sleep: alpha wave intrusion

Question 15

At the time of FMS diagnosis, mood disorders are present in _________ primarily depression. Increased prevalence of mood disorders is primarily in tertiary-referral patients. Overlap of neurochemical abnormalities in FMS and depression

Answer 15

At the time of FMS diagnosis, mood disorders are present in 30-50%, primarily depression. Increased prevalence of mood disorders is primarily in tertiary-referral patients. Overlap of neurochemical abnormalities in FMS and depression

Question 16

FMS treatment

Answer 16

education, pharmacology and non-pharmacologic

Question 17

non-pharmacologicFMS

Answer 17

education, aerobic exercise and cognitive behavior therapy

Question 18

No benefit from corticosteroids or nonsteroidal anti-inflammatory drugs in FMS

Answer 18

yep

Question 19

“Injuries to the musculoskeletal and nervous system that may be caused by repetitive tasks, forceful exertions, vibrations, mechanical compression, or sustained or awkward positions”.

Answer 19

repetitive strain injuries

Question 20

inflammation in repetitive strain injuries

Answer 20

nope

Question 21

Risk factors for repetitive strain injuries often divided into__________ (pertaining to properties of an individual’tendon or healing capacity) and ___________ pertaining to the load placed on the tendon

Answer 21

Risk factors for repetitive strain injuries often divided into intrinsic factors (pertaining to properties of an individual’tendon or healing capacity) and extrinsic factors pertaining to the load placed on the tendon

Question 22

histo in repetitive strain injuries

Answer 22

increase in tenocytes

Question 23

Age
Gender
Biomechanical abnormalities
Prior injury
? Genetic predisposition

Answer 23

intrinsic factors

Question 24

Training errors
Poor environmental conditions
Inadequate equipment
Fluoroquinolone antibiotics

Answer 24

extrinsic factors

Question 25

why is GC therapy is potentially harmful?

Answer 25

May inhibit collagen synthesis and increase rupture risk