PHARM interactions and side effects Flashcards
Hypokalemic drugs
Diuretics (Furosemide, HCTZ)
Corticosteroids (Hydrocortisone, Prednisone, Dexamethasone)
Cardiac glycosides (Digoxin, Convallaria, Digitalis, Leonarus)
Anti-Arrhythmias (atenolol, propranolol, amiodarone)
Pseudoephedrine
Glycyrrhiza
What meds caused decreased effects of Amoxicillin
tetracycline (Doxycycline, minocycline - protein synth inhib; mirtazapine - for MDD)
Penicillin increases effect and toxicity of what drug
methotrexate
Penicillin decreases effect of what drug class
Beta blockers
Penicillin’s effectiveness is decreased if it’s taken with what antibiotic
Doxycycline
Cephalexin, a cephalosporin (works like Penicillins), may increase effects of what drug
Metformin
A/E of Cephalexin
- C. diff super infection
- diarrhea
- pseudomembranous colitis (higher incidence than other antibiotics)
Fluoroquinolone Ciprofloxacin’s absorption is decreased by what
cations (antacids, iron, zinc, bismuth)
Ciprofloxacin increases serum levels of what drug
warfarin
Nitrofurantoin has antagonistic effects with what antibiotic class
Fluoroquinolones (Ciprofloxacin)
A/E of Nitrofurantoin
PAIN mnemonic
- Pulmonary toxicity
- Anemia in Pts with G6PD
- Irritated GI
- Neurotoxicity
A/E of Doxycyline
- permanent teeth discoloration
- black tongue
- photosensitivity
- GI distress
Doxycycline’s absorption is reduced when used with
antacids, calcium, Magnesium, Iron
Doxycyline decreases effect of what other antibiotic
Penicillin
What antibiotic class is safe for pregnancy
Macrolide (Azithromycin)
antibiotics that prolong QT
Azithromycin and Ciprofloxacin (macrolide and fluoroquinolone)
what kind of antacids reduce rate of absorption of Azithromycin
aluminum and magnesium salts
Trimethoprim-Sulfamethoxazole (TMP-SMZ; sulfonamide) induces folate deficiency which causes what Sxs
- thrombocytopenia/leukopenia
- megaloblastic anemia
(these are preventable with folic acid supplement)
What other drugs might cause additive folate deficiency with TMP-SMZ
- methotrexate
- phenytoin
which antidiabetic drug class does TMP-SMZ affect and how?
Sulphonylureas (increases hypoglycemic effect)
What antimicrobial is usually Rx for impetigo
topical Mupirocin
condition C/I with topical Mupirocin
burns
What anticholinergic antiviral drug is used in parkinsons and herpes zoster (and formerly influenza A)
Amantadine
Amantadine enhances effects of what drugs
- anticholinergics and levodopa