Pharm- Ed Flashcards
1
Q
Alprostadil- Names
A
Caverject, Muse
2
Q
Alprostadil- Indications
A
ED
3
Q
Alprostadil- MOA
A
Vasodilation by relaxing arterial smooth music.
4
Q
Alprostadil- Pt Ed
A
- Injection in lateral aspect
- Begins within 5-20 min, lasts an hour
5
Q
Alprostadil- AE
A
- Priapism
- Pain & swelling
- Penile curvature
6
Q
Sildenafil (Viagra)- MOA
A
- PDE-5 inhibitor, enhances effect of NO
- Increases penile blood flow
7
Q
Tadalafil (cialis)- MOA
A
- PDE with slower onset and longer 1/2 life
8
Q
Sildenafil (Viagra)- AE
A
- Color vision changes
- nasal flushing
- CV risk factors
- Don’t take with nitrates, alpha blockers
9
Q
Leuprolide- Indications
A
- Prostate CA
- Brease CA & endometriosis
10
Q
Leuprolide- MOA
A
- Inhibition of synthesis of androgen and estrogen in pituitary
- GnRH agonist
11
Q
Flutamide- Indications
A
- Prostate CA, in conjunction of leuprolide
12
Q
Flutamide- MOA
A
- Antiandrogen agent
- Competes with natural hormone binding site
13
Q
Flutamide/ leuprolide- AE
A
- Hot flashes, impotence & gynecomastia
- Nausea & diarrhea
14
Q
5 alpha reductase inhibitors- Names
A
Finistride & dutasteride
15
Q
5 alpha reductase inhibitors- MOA
A
Reduces size of prostate gland
