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Year 2 Psych exam2 > Pharm, Drugs for Obesity Martin > Flashcards

Pharm, Drugs for Obesity Martin Flashcards

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1
Q

phentermine and topiramate ER

A

most efficacious
>5% weight loss after 56 weeks at highest dose
avg patient went from 260 - 232 lbs

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2
Q

side effects phentermine topiramate (qsymia)

A

discontinuation ~40%
CI in pregnancy
only available through restricted access program designed to prevent fetal exposure

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3
Q

orlistat

A

OTC or Rx

pancreatic and gastric lipase inhibitor that dec absorption of fat

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4
Q

adverse effects orlistat

A 
flatulence with discharge
oily spotting
fecal urgency after high fat indescretions
discontinuation
CI during pregnancy
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5
Q

Lorcaserin

A

selective serotonin 2C agonist suppresses appetite

shcedule IV controlled substance

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6
Q

patients who should stop taking lorcaserin

A

fail to lose >5% baseline weight by 12 weeks

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7
Q

adverse effects lorcaserin

A

HA nausea dizziness
CI pregnancy
do not take with MAOI SSRI SNRI

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8
Q

bupropion/naltrexone

A

appetite suppressant/opoid R antagonist

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9
Q

adverse effects bupropion/naltrexone

A

nausea (main reason discontinue)
vomiting, HA, constipation, dizziness and dry mouth
neuropsychiatric reactions

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10
Q

liraglutide

A

injectable GLP-1 agonist used in DM II

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11
Q

adverse effects liraglutide

A

nausea, vomiting, constipation and diarrhea

slows gastric emptying and may dec rate and extent absorption of other drugs

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12
Q

box warning on liraglutide

A

thyroid C cell tumors

CI in pregnancy

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13
Q

weight loss in DM on glucose lowering drugs

A

increase insulin sensitivity and may increase risk of hypoglycemia

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14
Q

which off label drug helps with modest weight loss

A

metformin

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15
Q

adjustable gastric banding

A

restrictive procedure not assoc with malabsorption

loss of excess weight over 10 years

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16
Q

sleeve gastrectomy

A

laparoscopic partial gastrectomy

loss of excess weight over 5 years

17
Q

roux- en Y gastric bypass

A

mixed restrictive and malabsorptive procedure that involves creation of proximal pouch of stomach and anastomoses to limb of jejunum, bypassing most stomach and duodenum
excess weight loss after 2 years

18
Q

safer gastric surgery

A

banding

19
Q

Tx for severe binge eating disorder

A

Vyvanse- used for ADHD

20
Q

most common adult eating disorder in US

A

severe binge eating disorder

21
Q

adverse effects Vyvanse (lisdexamefatamine)

A

dry mouth, insomnia, dec appetite, constipation, feeling jittery and anxiety

Year 2 Psych exam2 (13 decks)

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