Pharm - Diabetes Flashcards
Hallmark signs/symptoms of DM
Hyperglycemia (sustained)
Polyuria
Polydipsia
What FPG levels are considered impaired?
Btw 100 and 125
What OGTT levels are considered impaired?
140-199
What A1C level is associated with prediabetes?
5.7-6.4%
When should healthy adults be screened for DM?
At age 45 and every three years (if results are normal).
How to diagnose diabetes?
FPG 126** or above
2-h PG over 200** during OGTT
A1C over 6.5%**
Symptoms & random PG over 200.
What is primary goal of diabetes management/treatment?
Control blood glucose to PREVENT long-term complications.
(Goal is not feeling better. Glucose can feel good in the bloodstream.)
Controlling BP and lipids is also important.
What is the first-line oral therapy for DM2?
Biguanide (metformin)
MOA of biguanide
Decreases liver’s production of glucose
Increases sensitivity of liver and muscle tissues to glucose uptake.
Does metformin/biguanide target post-prandial or fasting?
Fasting (FPG)
(Usually have to control the FPG first. Better effect on CV risk. This is why we use metformin first).
Most common S/E of biguanide?
Diarrhea. This is why we start low and go slow.
What is the BBW for biguanide/metformin?
Lactic acidosis: don’t use if patient has renal impairment.
What are the other adverse effects of metformin/biguanide?
Metallic taste in mouth
B12 absorption inhibition
(And diarrhea)
MOA of sulfonylureas?
Binds to sulfonylurea receptors on beta cells, increasing insulin secretion.
Targets postprandial glucose (PPG)
(Not fasting).
This is why it’s not first-line.
Why do sulfonylureas get discontinued?
Have squeezed the last drop of insulin out of the beta cells… no more left.
Called “secondary burnout”
What is the big side effect for sulfonylureas?
Weight gain.
(Also hypoglycemia can occur).
(There’s a possibility of higher CV risk… still finding out.)
How do thiazolidinediones work?
-increases glucose uptake in muscles and adipose
-decreases glucose output by liver
(Insulin sensitized)
Targets FPG
What are the A/Es of Thiazolidinediones?
Weight gain
HF exacerbation
(BBW: HF warnings: weight gain over 3kg, acute edema, SOB or fatigue without any cause).