Pharm Chapter 15 Flashcards
What are the four physiologic functions of NSAIDS?
decrease inflammation, mild to moderate pain, antipyretic, inhibition of platelet aggregation
What is the gold standard related to NSAID agents
Aspirin
Why - very well studied, been known/used for a long time
Common abbreviations: Acetaminophen/Tylenol (APAP) and Aspirin (ASA)
Why is acetaminophen different from NSAIDs and ASA?
No anticoagulant or anti-inflammatory properties
Used w/Pts that need blood-thinners - helps with their pain and decreases bleeding risk.
What 3 compounds make up Eicosanoids?
Prostaglandins, thromboxane and leukotrienes
Inhibition of what enzyme will decrease prostaglandin and thromboxane production?
COX
Leukotrienes are particularly important as proinflammatory in which organ of the body?
Lungs
Excessive prostaglandin synthesis involved with:
inflammation, pain, fever, dysmenorrhea, thrombus
MOA of prostaglandins in pain?
increasing sensitivity of pain receptors to mechanical pressure
COX 1
beneficial PGs in GI mucosa protect stomach from acid, maintain renal function, regulating normal platelet activity
Affect stomach and kidney
COX 2
inflammatory mediator, pathology
Affect the heart
meloxicam typical inhibitor
Impact of NSAIDs on COX 1 results in?
decrease protection of GI mucosa; decreased renal function
Which drugs is also known as a salicylate?
Aspirin (acetaminophen)
Name 4 conditions for which ASA is beneficial:
colorectal cancer, pain and inflammation, vascular disorders, fever
Name 3 side effects of ASA and NSAIDs:
GI bleed, renal/kidney impairment, cardiovascular concerns (MI, angina/chest pain)
What is tylenol associated with?
Liver toxicity
