Pharm- Bone disease Flashcards
1
Q
Bisphosphonates- Names
A
- alendronate (Fosamax),
- risendronate (Actonel),
- pamidronate (Aredia),
- zoledronic acid (Reclast)
2
Q
Bisphosphonates- MOA
A
- Decrease osteoclast formation/ activation
- Increase osteoclast apoptosis
- Inhibit cholesterol pathway for osteoclast formation
- Net gain of bone mass
3
Q
Bisphosphonates- Indications
A
Pagets, bone METS, hyperCa++ of malignancy
4
Q
Bisphosphonates- AE/ CI
A
- DIarrhea, abd pain & musc pain
- Esophagitis & esophageal ulcers
5
Q
Bisphosphonates- Pt ed
A
Remain upright 30 min following administration
- Large glass of H2O to avoid esophagitis
6
Q
Selective estrogen receptor modulators- Names
A
raloxifene (Evista)
7
Q
Selective estrogen receptor modulators- MOA
A
- Reduces serum total and LDL cholesterol concentrations
8
Q
Selective estrogen receptor modulators- Indications
A
- Post menopausal bone loss
- Prevents osteoporosis and risk of hip fracture
- Reduced risk of invasive breast cancer
9
Q
Selective estrogen receptor modulators- AE
A
- VTE, hot flashes, & leg cramping
10
Q
Calcitonin- MOA
A
- Inhibits osteoclast and increases osteoblast activity
- Regulation of calcium via bone, renal & GI
11
Q
Calcitonin- Indications
A
- Relives pain associated with osteoporotic fracture
- Postmenopausal osteoporosis
12
Q
Calcitonin- AE
A
- GI, injection/ inhalation site reaction
- Hypersensitivity rxn
13
Q
Estrogen- Indications
A
- Postmenopausal prevention of osteoporosis
14
Q
Estrogen- MOA
A
Inhibit bone resorption
15
Q
Estrogen- AE
A
MI, stroke, HTN, thromboembolism
