Hypogonadism Flashcards
1
Q
Male hypogonadism- Eti
A
- Deficient testosterorne secretion by testes
2
Q
Male hypogonadism- Sx
A
- Delayed puberty
- Decreased libido
- ED, hot sweats, fatigue or depression
- Infertility, gynecomastia, HA
- Decreased body, axially, beard & pubic hair
- Loss of muscle mass increased fat, wt gain
- Normal testies
- Osteoporosis
3
Q
Male hypogonadism- Dx
A
- Low testosterone
- MRI for pituitary tumor
- BOne density
4
Q
Male hypogonadism-Tx
A
- Testosterone replacement- topical or transdermal
5
Q
Hypogonadatropic hypogonadism
A
- FSH & LH deficiency- hypothalamic or pituitary issue
- decreased testicle size
- Due to:
- Pituitary tumor, cushing/ adrenal insufficiency
- Thyroid hormone deficiency, malnourishment, hemochromatosis
6
Q
Hypogonadatropic hypogonadism- Dx
A
- Serum prolactin- prolacinemia
- Gynecomastia- androstenedione & esterone
- Estradiol- elevated
- Ferritin (hemochromatosis)
7
Q
Hypergonadatropic hypogonadism-
A
- Issue at sex organs, sufficient gonadatropins secreted from hypothalamus. pituitary
- Male climacteric
- Klinefelter
- Orchitis (gonorrhea, Tb, leprosy)
- Radiation/ chemo
- Autoimmune, torsion, dystrophy
8
Q
Hypergonadatropic hypogonadism- Dx
A
- Karyotype for klinefelter, leukocyte X-inactive specific transcriptase
9
Q
Female hypogonadism- Eti
A
Hyper- hypo: High LH/ FSH, low estrogen
- Issue at sex organ (Turner, ovarian failure, chemo)
Hypo-hypo: Low LH/FSH due to issue at hypothalamus/ pituitary
10
Q
Female hypogonadism- Sx
A
Delayed menarche,
- short stature,
- Delayed puberty
- Osteoporosis
- Infertility
- Hot flashes & vaginal dryness
11
Q
Female hypogonadism- Dx
A
- hCG
- Estradiol
- FSH
- PRL
- TSH
- Bone density
12
Q
Female hypogonadism- Tx
A
- Pre- puberty- Titrate estradiol to initiate puberty
- Post- puberty- Protect bone density, fertility, estradiol/ progesterone
