Pharm Antiinfective Drugs pt 2

Question 1

Acute pharyngitis

Answer 1

Penicillin V (PO) or Benz PCN (IM)
PCN allergy: Clindamycin
From GABHS
Clindamycin may lead to C diff

Question 2

Peritonsillar Abscess

Answer 2

Incision & Drainage, Amox/Clav
PCN allergy: Clindamycin
From mixed bacterial flora in the mouth/teeth

Question 3

Ludwig’s Angina

Answer 3

PCN G (IV) + Metronidazole (IV)
from Strep, Eikenella corodens, Polymicrobic

Question 4

Epiglottitis

Answer 4

Cefuroxime
Cefotaxime
Ceftriaxone
in PEDs: From H flu B, GABHS, strep pneumoniae, staph aureus
in adults: from H flu B, GABHS

Question 5

HSV I

Answer 5

Valacyclovir (PO) (prodrug -> Acyclovir)

Penicyclovir (TOP) - apply every 2 hours w/ Q-Tip

Question 6

CAP

Answer 6

Under 50: Main cause is Mycoplasma pneumonia. Tx: Azithromycin
>50: Main cause is Strep pneumoniae. Give an advanced Quinolone: Levofloxacin

Question 7

Acute Bronchitis

Answer 7

Main cause: viral
Beta-2 agonist (Albuterol). Consider adding a steroid
Amox/clav
Azithromycin (an advanced macrolide)
Levofloxacin (an advanced quinolone)
Bacterial bronchitis occurs in ppl with DM, COPD, and elderly

Question 8

Gastroenteritis (bacterial cause)

Answer 8

Adults: Ciprofloxacin, TMPSMZ, Erythromycin
PEDs/Preg: TMPSMZ & Erythromycin
Causes: Shigella, Campylobacter, Salmonella, Giardia lamblia

Question 9

Surgery prophylaxis/ Abdominal trauma

Answer 9

Simple surgery: Cefazolan
Complicated surgery: 2nd Gen Ceph
From Gram Negatives