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PBL Pharm Block 3 > Pharm 9 - Cholinergics > Flashcards

Pharm 9 - Cholinergics Flashcards

1
Q

Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane

A
  • Botulinum Toxin

- Produced by C. Botulinum

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2
Q

Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site. (5)

A
  • Edrophonium
  • Neostigmine
  • Pyridostigmine
  • Ambenonium
  • Physostigmine
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3
Q

Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis

A
  • Botulinum Toxin (BoTox)
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4
Q

Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)

A
  • Edrophonium
  • Neostigmine
  • Pyridostigmine
  • Ambenonium
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5
Q

Use for Reversal of anticholinergic toxicity or induced surgical paralysis

A
  • Physostigmine
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6
Q

Has direct cholinergic agonist effect at Nm receptors

A
  • Neostigmine
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7
Q

Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor

A
  • Cholinesterase Inhibitors
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8
Q

AChE Inhibitor encountered as a toxin, used as an insecticide

A
  • Diisopropyl Fluorophosphate
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9
Q

AChE Inhibitor Used for Alzheimer’s Disease and Dementia

A
  • Tacrine, Donepezil, and Rivastigmine
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10
Q

Stimulate Muscarinic Receptor Activity (Muscarinic Receptor Agonists)

A
  • Methacholine
  • Carbachol
  • Bethanechol
  • Cevimeline
  • Pilocarpine
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11
Q

Used to Diagnose Asthma

A

Methacholine

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12
Q

Muscarinic Receptor Agonist Used for Glaucoma

A
  • Carbachol
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13
Q

Muscarinic Receptor Agonist Used for Urinary Tract Motility

A
  • Bethanechol
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14
Q

Muscarinic Receptor Agonists Used for Xerostomia in Sjogren’s Syndrome

A
  • Cevimeline and Pilocarpine
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15
Q

Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation

A
  • Methacholine
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16
Q

Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)

A
  • Succinylcholine
17
Q

Used to induce neuromuscular blockade in surgery and for intubation

A
  • Succinylcholine
18
Q

Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure

A
  • Succinylcholine
19
Q

Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning

A
  • Atropine
20
Q

Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision

A
  • Atropine
21
Q

Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch

A
  • Scopolamine
22
Q

Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia

A
  • Pirenzepine, Methscopolamine, and Glycopyrrolate
23
Q

Muscarinic Receptor Antagonist Used for Asthma and COPD

A
  • Ipratropium and Tiotropium
24
Q

Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence

A
  • Oxybutynin, Propantheline, and Terodiline
25
Q

Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)

A
  • Pancuronium, Tubucurarine, Vecuronium

- Trimethaphan and Mecamylamine

26
Q

MOA of Edrophonium, Neostigmine, Pyridostigmine, Ambenonium and Physostigmine

A

Acetylcholinesterase Inhibitors

27
Q

MOA of Pancuronium, Tubucurarine, Vecuronium, Trimethaphan and Mecamylamine

A

Nicotinic Receptor Antagonists

28
Q

MOA of Oxybutynin, Propantheline, and Terodiline

A

Muscarinic Receptor Antagonists

29
Q

MOA of Ipratropium and Tiotropium

A

Muscarinic Receptor Antagonists

30
Q

Pirenzepine, Methscopolamine, and Glycopyrrolate

A

Muscarinic Receptor Antagonists

31
Q

MOA of Tacrine, Donepezil, and Rivastigmine

A

AChE Inhibitors

PBL Pharm Block 3 (14 decks)

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