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PBL Pharm Block 3 > Pharm 10 - Adrenergics > Flashcards

Pharm 10 - Adrenergics Flashcards

1
Q

rate limiting enyzme for catecholamine synthesis and the sole inhibitor of it

A

tyrosine hydroxylase; alpha- methyltyrosine

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2
Q

MOA of the inhibitors of catecholamine storage (ICS)

A

short term increase in catecholamine but long term depletion of available pool of catecholamines

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3
Q

Inhibitor of Catecholamine Storage used for hypertension (3)

A

Reserpine, guanethidine, guanadrel

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4
Q

Inhibitor of Catecholamine Storage used for ADHD and narcolepsy

A

amphetamine (narcoleptics) , methylphenidate

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5
Q

Inhibitor of Catecholamine Storage used for allergic rhinitis and Nasal Congestion

A

Pseudoephedrine

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6
Q

ADR : GI hemorrhage, thrombocytopenia, dream anxiety disorder impotence and psychotic depression

A

Reserpine

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7
Q

ADR: kidney disease , apnea , orthostatic hypotention fluid retention, dizzines , blurred vision, impotence

A

Guanethidine , guanadrel

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8
Q

ADR: hypertension, tachyarrhythmia, Gilles de la Tourettes syndrome, seizure psychotic disorder w/ prolonged use

A

Amphetamine, Methylphenidate

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9
Q

ADR: A-fib, Ventricular Premature Beats, MI, insomnia, tachyarrhythmia, hypertension

A

Pseudoephedrine

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10
Q

Irreversibly inhibits VMAT but rarely used because of its association with psychotic depression

A

Reserpine

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11
Q

Displaces norepinephrine from the storage vesicles. and can lead to reduced Cardiac Output

A

Guanethidine, Guanadrel

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12
Q

Displace endogenous catecholamines and also weakyl inhibit MAO and block reuptake at NET and DAT, dependence is possible

A

Amphetamine, Methylphenidate

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13
Q

Inhibitors of Catecholamine Reuptake and at what receptor

A

Cocaine, Imipramine, and Amitriptyline@NET

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14
Q

INhibitors of MAO

A

PICTureS of BoMBs

  • Phenelzine
  • Iproniazid
  • clorgyline
  • Tranylcypromine
  • Selegine
  • Befloxatone
  • Moclobemide
  • Brofaromine
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15
Q

Alpha1-adrenergic agonists (4) and Mechanism

A
  • Phenylephrine, Oxymetazoline, Tetrahydrazoline, Methoxamine (MethPhenOxyTet)
  • Activates central Alpha1-adrenergic auto receptors to Increase peripheral resistance
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16
Q

Indicated for Opthalmic hyperemia and Nasal Congestion

A

Phenylephrine (can use in hypotension), Oxymetazoline, Tetrahydrazoline

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17
Q

ADR bradycardia, ventricular ectopic beat

A

methoxamine

18
Q

ADR: cardiac arrythmia + hypertension. rebound nasal condition

A

Phenylephrine, Oxymetazoline, Tetrahydrazoline

19
Q

Alpha-2 adrenergic antagonists (5) and their MOA

A
  • Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
  • Activate central alpha2-adrenergic auto receptors to inhibit sympathetic outflow from CNS
20
Q

sedation of surgical and ICU pts

A

dexmedetomidine

21
Q

used for Opioid withdrawl or cancer pain

A

Clonidine

22
Q

ADR: hepatotoxicity, autoimmune hemolytic anemia

A

methyldopa

23
Q

ADR : bradycardia and heart failure (4)

A

Clonidine, Dexmedetomidine, Guanabenz, Guanafacine

24
Q

Used for Hypertenion assoc. with opioid withdrawl

A

Clonidine

25
Q

DRUG OF CHOICE for hypertension during pregnancy

A

Methyldopa

26
Q

Beta-adrenergic agonists

A
  • Metaproterenol, Isoproterenol, Salmeterol, Terbutaline, Albuterol, Dobutamine
  • (Mista D)
27
Q

Alpha-adrenergic antagonists MOA

A

block alpha 1 and 2 causing vasodilation, decreased BP and decreased peripheral resistance.

28
Q

Use for Pheochromocytoma-associated hypertension and sweating and Pre-Operative Management of Pheochromocytoma

A
  • Phenoxybenzamine and Phentolamine
29
Q

Use for Benign Prostatic Hyperplasia

A
  • Osins!

- Prazosin, Terazosin, Doxazosin, and Tamsulosin

30
Q

First Dose of these is generally prescribed in small quantities at bedtime due to potential severe postural hypotension

A
  • Zosins!

- Prazosin, Terazosin, Doxazosin

31
Q

Use for Organic and Psychogenic Impotence

A
  • Yohimbine
32
Q

Adverse Effects Include Bronchospasm, nervousness, tremor, increased blood pressure, and increased insulin release.

A
  • Yohimbine
33
Q

Alpha1-receptor Antagonist that has more specificity toward smooth muscle in genitourinary tract

A
  • Tamsulosin
34
Q

Beta-Adrenergic Antagonists and Major Use

A
  • “Olol” Drugs

- Hypertension and Angina

35
Q

Beta Antagonist Used for Glaucoma

A
  • Timolol
36
Q

Beta and Alpha1 Antagonists

A
  • Labetalol and Carvedilol
37
Q

Partial Agonists Among Beta Antagonists

A
  • Pindolol and Acebutolol
38
Q

Partial Agonist at Beta 1 and 2 receptors preferred in hypertensive patients who have bradycardia or decreased cardiac reserve

A
  • Pindolol
39
Q

Used for Emergency Beta Blockade, as in Thyroid Storm because of short half life

A
  • Esmolol
40
Q

Extremely lipophilic; CNS concentration is high enough that sedation and decreased libido may result

A
  • Propanolol
41
Q

Beta1 Selective Antagonists

A
  • Esmolol, Metoprolol, Atenolol

PBL Pharm Block 3 (14 decks)

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