Pharm 3 Cardio Flashcards
Numodipine
Calcium Blocker
- Most lipid soluble
- Cerebral Vasodilator
Diltiazem
Benzothiazipine
Calcium Blocker
- Less tachycardia
- Depress SA & AV
- ↓ contractility
- Bradycardia
- C/I SA &AV node abnormalities/CHF
- Aterioles>Veins
- INHIBIT INSULIN; Interfere plate agg
- ↑ plasma Digoxin
Captopril
- ACE inhibitor (peptidyl dipeptidase)
- Increases Angioten I & Bradykinin
- Bradykinin → ↑ PG syn → vasodilation
- No reflex sympathetic
- Young Caucausians (mono therapy ok)
- DOC: DM, chronic renal, LV hypertropy
- Synergistic with diuretics
- Cough, hyperkalemia, angioedema, acute renal failure w/ B/L stenosis, hypotension
- C/I Pregnancy, K+ diuretics, NSAIDS (block bradykinin
- active drug (all other ACEI are prodrugs)
**ACEI don’t compromise HEART, KIDNEY, or BRAIN
Verapamil
Papaverine
Calcium Blocker
- strongest Cardiac Effect
- Less tachycardia
- Depress SA & AV
- Constipation
- Bradycardia
- Aterioles>Veins
- INHIBIT INSULIN; Interfere Plate Agg
- ↑ plasma Digoxin
Nifedipine
Dihydropyridines
- Calcium Blocker
- Strongest Vaodilator
- ↓ afterload ↑o2 supply
- Reflex tachycardia
- Vascular Side Effects
- Gingival hyperplasia
- Less SA AV effect
- INHIBIT INSULIN; Interfere -Plate Agg
- ↑ plasma Digoxin
- Slow release HPT
Losartan
- Inhibit AT1 (ATII receptor) → ↑ ATII
- No bradykinin effect
- SE: hyperkalemia, acute renal failure w/ B/L stenosis (?), hypotension
- Fetal Toxicity
- Does not cause cough/angioedema
- More effective lowering mortality Atenolol
Ranolazine
- Partial fatty-acid oxidation inhibitor
- ↓ left ventricular wall stiffness
- Oral
- Inhibits late sodium
- Metabolized by CYP3A= drug interactions
- C/I: hypokalemia, Heart rhythym abnormalities
Nitroglycerin
- ↑ cGMP
- ↓ preload ↓afterload
- Can ↑ workload by reflex tachycard
- ↓ O2 requirement & redistribute bf to ischemic
- ↓ platelet aggregation
- Acute hypotension, THROBBING headaches
- Tolerance, “Monday Disease”
- High first pass effect
- Sublingual avoids hepatic
Aliskiren
-Renin Antagonist block ang I
-Hypertension
Hepatobiliary clearance
Headache
Dizziness
GI events
C/I Pregnancy 2nd 3rd Trimesters Categ D
Sildenafil
-Selective inhibior of cGMP phosphodiesterase
-PDE5
-Helps with Impotence
-Treats pulm hypertension
-PDE6 less potent EYE
-Metabol CYP 3A4
Adv Effect
-Nasal congestion, UTI,
-Visual Impairment
-C/I: pregnant/children, NITRATES, alpha blockers
Verdenafil
- Like sildenafil
- More selective for PDE5>6
- Faster onset
Dorzolamide
Brinzolamide
- Inhibit Carbonic Anhydrase
- Topically for Glaucoma
Furosemide
- Loop Diuretic/ Inhibit NaK2Cl thick asc
- ↑ excr Mg & Ca
- TREAT: CHF, Edema, HyperCalc, excess K
- HYPOKALEMIA & ALKALOSIS
- ↑ PG synthesis, Relieve PULM Congestion
- Hyperuricemia
- OTOTOXICITY w/ aminioglycosides
- Thrombocytopenia, Allergies
- DI: Aminoglyc, Lithium, Digoxin
- C/I Sulfonamide, hep cirrhosis, renal fail, dangerous in CHF
Ethacrynic Acid
- Loop Diuretic
- Same Adverse Effects
- Not a sulfonamide
- Higher risk of OTOTOXICITY
Hydrochlorothiazide
-Inhibit Na/Cl resorption distal tubule
-Depends on PG synthesis (inhib by NSAID)
Uses
-HPTN, CHF, Nephrolithiasis, **Nephrogemoc DI
Effects
-↑ K opening, Lower BP, enhance antihyperten drugs
-Hypokalemia, Hyperuricemia, ↓ Ca excre, ↑Mg. Br, Iodine loss, Hyperglycemia ↓insulin
-↑ Lipids Blood, Dyscrasia, Necrotizing vasculitis, aggravate jaundice infants, Lithium Toxicity
Metolazone
- Similar to Thiazide,
- Produce diuresis in patients with reduced GFR
Indapamide
- Direct vasodilators
- Thiazide Like
- Hepatic metabolism
- No increase in Lipids
- PRONOUNCED Vasodilation
Spironolactone
-Competitive inhibitor of aldosterone
-Binds to glucocorticoid and sex hor receptors @ high doses
Toxicities
-GI, Impotence, GYNECOMASTIA,
-Hyperkalemia, Acidosis
-CAREFUL: w/ ACE inhib and ARB’s
-Most Effective in Hyperaldosteronism
Eplerenone
Selective Aldosterone Receptor Antagonist
- Simular to spironolactone, NO ENDOCRINE EFFECTS ↓ affinits gluco, androgen receptors
- REDUCE all cause mortality with M.I.
Triamterene
-Independent of aldosterone,
-Inhibits Dihydrofolate reductase
-Inhibit sodium potassium exchange distal tube
-NO CAUSE OF HYPERURICEMIA
Toxicity
-Hyperkalemia
-Nausea vomiting
Use
-Combo with K losing diuretics
-Edema w/ CHF,Cirrhosis, Nephrotic synd
-Hirutism.
Amiloride
-Independent of aldosterone,
-Inhibit sodium potassium exchange distal tube
-NO CAUSE OF HYPERURICEMIA
Toxicity
-Hyperkalemia
-Nausea vomiting
Use
-Combo with K losing diuretics
-Edema w/ CHF,Cirrhosis, Nephrotic synd
-Hirutism.
DOC: lithium induce Diab Inipidus
Mannitol
Osmotic Diuretic
-Freely Filtered @ glomerulus
-Pharmacologically inactive
-Inhibits water resorption at prox and loh
-DOC: less irritable, less likely thrombophlebitis
USES:
-↓ intraocular, ↓ intercranial, ↓ CSF, protect kidney form toxic agents, prophylaxis renal
Toxic - ↑ cerebral bf, dehydration, ECF expansion,
pulm edema CHF, headache
Vasopressin
- Exogenous form of ADH
- Parenteral
- Prevent or control poly-uria/dipsia & dehydration
Desmopressin
-Synthetic analog of ADH
-Long acting
-↑ coag VIII & vWF
USES:
-Ruptured esophagus varix bleeding
Conivaptan
- Non peptide v1 & v2 adh rec antagonists
- ↑ urine output ↓ resorption water
Cilostazol
Anti-platelt
- PDE3 inhib → ↑ cAMP
- TX intermittent claudication
Demeclocycline
- Tetracycline antibiotic
- Used to produce Diabetes Insipidus
- Uncouple v2 receptor
- Lower toxicity than lithium
Lithium
Uncouples v2 from adenylyl cyclase
Digitalis
Digoxin
-CardOut ↑ in CHF; Not in normal pt: ↓HR
-Use for atrial arrhythmias
-Inhibits Na/K ATPase
-↑ contractility, ↑ free Ca ↑intra Na
-K counters Digitalis;Digitalis counters K
-Mg and K ↓ toxicity
-Hockey Stick Config
-Narrow Marg of Saftey: L
ADV EFF: arrhythmias, CNS, and skin irrit
DO NOT USE CARDIOVERISON
C/I: WPW syndrome
Digoxin
Drug Interactions
Enhance toxicity:
- ↓ Renal Clearance & ↓ VD:
- -(quinidine, amiodarone, verapamil, diltiazem, captopril)
- ↑ GI Absorption
Reduce Toxicity:
-↓ GI absorption: Cholestyramine ↓ absorption
QUINIDINE: ↑ plasma levels displaces from protein
DIURETICS: cause hypokalemia= ↑toxicity
ELDERLY: ↑ levels b/c hypochloridia/↓ Clearance
INFANTS: ↑ Dose
Hypothyroid: ↓renal CL ↑ plasma levels
Use: Lidocaine, Phenytoin or Propranolol for intox
Milrinone
-Inodilator or bipyridine
-Inhibit PDE, ↑ cAMP
-↑ Ca influx
-Vasodilatory
-ACUTE: ↑ CardOut CHRONIC: ↓ survival
Toxicites
-Arrhythmias, thrombocytopenia, nausea
USE FOR ACUTE HEART FAILURE
Inamrinone
stop here
-Inodilator or bipyridine
-Inhibit PDE, ↑ cAMP
-↑ Ca influx
-Vasodilatory
ACUTE: ↑ CardOut CHRONIC: ↓ survival
Toxicites
-Arrhythmias, thrombocytopenia, nausea
USE FOR ACUTE HEART FAILURE
Dopamine
-Sympathomimetic USE: Severe refractory CHF & Post op heart -↑ Cardiac Output ↑ RBF -↓ p. resistance -↑ Na excretion -Can treat shock -IV Admin
Levosimendan
Pimobendan
- Calcium Sensitizers
- ↑ calcium sensitivity w/out ↑ tissue calcium
- Inhibit PDE III
- Sensitizes troponin-C
Dobutamine
- Sympathomimetic
- Selective B1
- Less Tachycardia
- ↑ O2 consumption
- Reduced filling pressure
- IV admin
Nesiritide
- Analog of BNP
- Acute Tx of decompensated CHF
- Causes ↓ Pulm Wedge Press
- Improves Dyspnea and Fatigue
- Lack of tolerance (unlike Nitroglycerin)
MONITOR BP, hypotension
Beta Blockers CHF
Bisoprolol, Carvedilol Metoprolol
-Dangerous in severe CHF
-↓ mortality rates class II and III CHF
USED in Diastolic Dysfunction & cardiomyopathy
Benefits
- Attenuation catecholamines
- ↑ beta receptors
- ↓ HR ↓ Remodeling
- Antiarrhythmic effect (UNIQUE)
Sodium Nitroprusside
- Used in CHF helps with preload after load
- IV for HTN emergencies (↑ infusion = ↓ BP & visa versa)
- Vasodilator Art and Veins (veins > arteries)
- ADVERSE: Excessive Hypotension
- Metabolized to thiocyanate: CYANIDE POISONING
- Can cause metabolic acidosis
- Sodium Nitrite → methemeglobin → Tx CN poisoning