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year 2 > Liver damage patterns > Flashcards

Liver damage patterns Flashcards

1
Q

microvesicular steatosis

A

can cause acute liver failure

  • tetracycline
  • pregnancy
  • valproate
  • Reye syndrome
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2
Q

Pattern of Injury:
-Cholestatic

Morphology:
-bland hepatocellular cholestasis w/o inflammation

A
  • contraceptives/estrogen
  • anabolic steroids
  • Abx
  • HAART
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3
Q

Pattern of Injury:
-cholestatic hepatitis

Morphology:
-cholestasis w/ lobular necroinflammation w/ or w/o duct destruction

A
  • Abx
  • Statins
  • Phenothiazine
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4
Q

Pattern of Injury:
-Hepatocellular necrosis

Morphology:
-spotty necrosis

A
  • methyldopa

- phenytoin

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5
Q

Pattern of Injury:
-Hepatocellular necrosis

Morphology:
-massive necrosis

A
  • acetominophen

- halothane

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6
Q

Pattern of Injury:
-Hepatocellular necrosis

Morphology:
-chronic hepatitis

A

-isoniazid

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7
Q

Pattern of Injury:
-fibrosis & cirrhosis

Morphology:
-periportal & pericellular

A
  • alcohol
  • methotrexate
  • enalopril
  • vit A & retinoids
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8
Q

Pattern of Injury:
-Granulomas

Morphology:
-noncaseating epithelioid

A
  • sulfonamides
  • amiodarone
  • isoniazid
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9
Q

Pattern of Injury:
-Granulomas

Morphology:
-fibrin ring granuloma

A

-Allopurinol

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10
Q

Pattern of Injury:
-Fatty liver

Morphology:
-large & small droplet

A
  • EtOH
  • corticosteroids
  • methotrexate
  • TPM
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11
Q

Pattern of Injury:
-Fatty liver

Morphology:
-steatohepatitis w/ mallory-denk bodies

A
  • EtOH (acetaldehyde)

- Amiodarone

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12
Q

Pattern of Injury:
-Fatty liver

Morphology:
-steatohepatitis w/ mallory-denk bodies

A
  • EtOH

- Amiodarone

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13
Q

Pattern of Injury:
-Vascular lesion

Morphology:
-sinusoidal obstruction/ veno-occlusion of central vein

A
  • high does chemo

- bush teas

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14
Q

Pattern of Injury:
-Vascular lesion

Morphology:
-Budd-Chiari: hepatic vein occlusion

A

-oral contraceptives

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15
Q

Pattern of Injury:
-Vascular lesion

Morphology:
-Peliosis hepatitis (dilation of sinusoids)

A
  • anabolic steroids

- tamoxifen

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16
Q

Pattern of Injury:
-Neoplasm

Morphology:
-hepatocellular adenoma

A
  • oral contraceptives

- anabolic steroids

17
Q

Pattern of Injury:
-Neoplasm

Morphology:
-hepatocellular carcinoma

A
  • EtOH

- thorotrast

18
Q

Pattern of Injury:
-Neoplasm

Morphology:
-cholangiocarcinoma

A

-Thorotrast

19
Q

Pattern of Injury:
-Neoplasm

Morphology:
-angiosarcoma

A
  • thorotrast
  • vinyl chloride
  • arsenic

year 2 (15 decks)

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