Pharamaologu Flashcards
Paracetamol- Acetaminophen what does it do
penetrates the blood barrier,
blood cox3 in brain
, blocks formation and release prostaglandins in CNS,
inhbits the action of endogenous pyrogens
on the heat-regulating centres in the brian
Aspirin inhibits what
the conversion of phosopohilds into arachidonic acid
NSAIDS selective vs non selective
Non-selective: inhibit both cox1-cox2 pathways
ibuporfen, volatren, nurgoen
Selective: inibits cox 2 l
Brands mobic: celebrex
Cox1- vs cox2
COX 1- produces prostaglandins that promote infalmmation, pain, fever as we as activating platelts and proctecing the stomach and intestinal lining
Cox2 produces prostaglaninds that promote inflammtion, pain and fever
NSAIDs function?
work by inhibiting prostaglandin synthesis by inhibitng COX (cyclooxygenase)
how can medication can affect analgesia
decrease ascending input (transduction &transmission)
lower inflammatory mediators
sensitivty of nociceptive receptors
block peropheral sesnory nerve conduction
Change pain perception: modyify neurontransmitters iun the sensory cortex of limbic system
Increase Descending modulation
change level of neruontransmitter pathyway
Pharmacological Management if Pain
- Transduction, inhibtion of neurons that are stimulated by nociceptor
- Transmission inhibtion of nervbe impluses in the PNS and CNS
- Modulation
- Perception
Pharamacokinectics
what the body does to drug
Absorption, distrbution, metabolism, excertion
Pharamacodynamics
what the durg does to the body
drug conecntration at the site of the of action, pharamcoloigc effect,
clinical respone, effectiveness, toxicity
routes of administartion
enteral: oral, sublingual, rectal
Parenteral: intravenous,intramuscular, subcutaneous
Topical Routes: conjuctive, nasal, auditory
6 rights of drug therpay admininstration
right person, medication, dose, time, route, documentation
Pharamacodynamics
drug concentration at the site of the action
pharmacologic effect, clinical response, effectiveness, toxicity
