PGs and Leukotrienes

Question 0

Prostaglandin F2a (PGF2a)

Answer 0

Agonist at smooth muscle
Vasoconstrictor Bronchoconstrictor
Pathogenic in asthma

Question 1

Thromboxane A2 (TXA 2)

Answer 1

Agonist at platelets and smooth muscle

Vasoconstrictor Bronchoconstrictor Platelet Aggregant

Question 2

Aspirin

Answer 2

PROSTAGLANDIN SYNTHESIS INHIBITOR
Irreversible acetylation of serine on COX-1,2
Analgesia, Antipyretic, Antiinflammatory Stops platelet TXA2
Bleeding, GI erosion Not to be used in children:risk of Reyes syndrome

Question 3

Leukotrienes C4 and D4

Answer 3

Receptor agonists at Leucocytes, smooth muscle, vascular muscle
Bronchoconstrictors Attract and activate leukocytes
Tox: Inflammation Bronchoconstriction Edema

Question 4

Zileuton

Answer 4

LEUKOTRIENE MODIFIERS
Blocks lipoxygenase
Decrease LT synthesis in asthma

Question 5

Zafirlukast

Answer 5

LEUKOTRIENE MODIFIERS
C4 and D4 receptor blocker
Decrease LT action in asthma
Tox: Churg Strauss syn (systemic eosinophilic vasculitis) when steroid dose dec

Question 6

Montelukast

Answer 6

LEUKOTRIENE MODIFIERS
C4 and D4 receptor blocker
Decrease LT action in asthma
Tox: GI distress, bleeding and hypersensitivity