ACE Inhibitors Flashcards
0
Q
Enalapril, Ramipril, Quinapril, other -pril drugs
A
ACE-I Pro-drugs
1
Q
Captopril and Lisinopril
A
ACE-I Direct-acting, sulfur- containing drugs
Captopril’s CATCHH (cough, angioedema, teratogen, creatinine inc, hyperK, HypoTN)
2
Q
Enalaprilat, Ramiprilat
A
ACE-I Active metabolites
3
Q
Usefulness and toxicities of ACEI
A
Usefulness: lower BP in HTN pts with elevated renin, ID hypertensives w/o high renin, improve CHF; good in diabetics
Tox: (captopril’s) CATCHH
No ACE means Bradykinin not broken down –> dec TPR and BP
Acute renal failure
HyperK (bc dec of aldosterone)
