Drugs For TB

Question 0

Rifampin (RIF)

Answer 0

Inhibits DNA- dependent RNA Polymerase
Rec for ppl who can’t tolerate INH
Bactericidal Inducer of CYP enzymes is big problem.
Resistance, hepatotoxicity, FLU-LIKE SYNDROME, red fluids (discoloration of urine, sweat, tears)

Question 1

Isoniazid (INH)

Answer 1

Inhibits glycolic acid synthesis. Cell wall disruption
Bacteriostatic &Bacteriocidal Slow acetylators – greater toxicity. Resistance, rash, liver tox., bone marrow, neurotox. Add pyridoxine (Vit B6)

Question 2

Pyrazinamide (PZA)

Answer 2

MOA: Unknown

Bactericidal No CYP induction Resistance Liver toxicity, hyperuricemia, N/V, rash, arthralgia

Question 3

Ethambutol (EMB)

Answer 3

Inhibits arabinosyl transferases, Cell wall disruption
Bactericidal
Tox: Optic neuritis

Question 4

Rifabutin

Answer 4

MOA: Inhibits DNA- dependent RNA Polymerase
Bactericidal
No enzyme induction. Renal elimination.
Tox: Hepatotoxicity, flu- like, Orange-brown fluids, vision changes, bleeding, yellow eyes and skin

Question 5

Rifapentine

Answer 5

MOA like Rifampin and Rifabutin
Bactericidal Inducer of CYP enzymes is a big ptoblem
Tox: Resistance, hepatotoxicity, flu-like syndrome, red fluids